Utility of magnetic resonance imaging in determining treatment response and local recurrence in nasopharyngeal carcinoma treated curatively

BMC Cancer
Katherine MengTimothy Cheo

Abstract

To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for locoregional recurrence (LRR). Patients with non-metastatic NPC treated radically who had at least one post-treatment MRI (ptMRI) done were included for analysis. ptMRI reports were retrospectively reviewed and categorised as complete response (CR), partial response/residual disease (PR) or indeterminate (ID). Patients with LRR were assessed to determine if initial detection was by MRI or clinical means. Univariable and multivariable Cox proportional hazard regression analysis were performed to identify independent factors associated with CR on ptMRIs. Between 2013 and 2017, 262 eligible patients were analysed, all treated with Intensity Modulated Radiotherapy (IMRT). Median time from end of RT to the first ptMRI was 93 days (range 32-346). Of the first ptMRIs, 88 (33.2%) were CR, 133 (50.2%) ID, and 44 (16.6%) PR. A second ptMRI was done for 104 (78.2%) of 133 patients with ID status. In this group, 77 (57.9%) of the subsequent MRI were determined to be CR, 21(15.8%) remained ID and 6 (4.5%) PR. T1 tumour stage and AJCC st...Continue Reading

References

Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·P OlmiG Giannardi
Jan 1, 1994·Auris, Nasus, Larynx·M Fujii, J Kanzaki
Nov 14, 1997·Neuroradiology·S H NgM H Tsai
Jun 6, 2000·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·N PengR Liu
Jul 19, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Siew-Shuen ChaoLuke K S Tan
Nov 27, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tao LiuGang Huang
Jun 19, 2013·Oral Oncology·Vincent Lai, Pek Lan Khong
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Nov 15, 2016·The Journal of Laryngology and Otology·R SimoS Hickey
May 13, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·A Dimitrios ColevasSusan D Darlow

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Citations

Dec 19, 2020·Open Medicine·Zhang EYuandi Xiang

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Methods Mentioned

BETA
biopsy
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