Utility of measuring C-reactive protein for prediction of in-hospital events in patients with acute aortic dissection.

Heart and Vessels
Norihito OkinaTsutomu Imaizumi

Abstract

Controlling blood pressure is essential for prevention of events after acute aortic dissection (AAD). However, in some instances a cardiac event occurs despite controlled blood pressure, and its prediction is difficult. We continuously monitored C-reactive protein (CRP) in patients receiving medical treatment for AAD and retrospectively examined the utility of CRP measurement for prediction of in-hospital events. Five hundred and eight patients were diagnosed as having AAD between 1993 and 2009, 240 of whom underwent antihypertensive medical therapy. These subjects were 156 males and 84 females, average age 67.4 years, with 68 cases of Stanford type A and 172 cases of Stanford type B. C-reactive protein was measured in all patients daily until a peak; subsequently, CRP was measured 2-3 times per week following the peak until discharge. In the event-free group CRP demonstrated a peak on the 4th day after the onset (average 13.7 mg/dl), then gradually decreased to an average of 4.6 mg/dl 4 weeks later, displaying a "gradual decay" pattern. Despite controlled systolic arterial pressure of approximately 120 mmHg, 7 of 68 Stanford A cases (10.3 %) and 8 of 172 Stanford B cases (4.7 %) developed cardiovascular events. The group chara...Continue Reading

References

Jul 11, 2002·Intensive Care Medicine·Martin SchillingerMarcus Müllner
Jul 27, 2007·The New England Journal of Medicine·Thomas T TsaiUNKNOWN International Registry of Acute Aortic Dissection
Nov 11, 2008·The New England Journal of Medicine·Paul M RidkerUNKNOWN JUPITER Study Group
Apr 4, 2009·Journal of the American College of Cardiology·Rozenn QuarckMarion Delcroix
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Olle MelanderThomas J Wang
Sep 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Evaldas GirdauskasFriedrich-Wilhelm Mohr
Oct 2, 2009·Journal of Cardiothoracic Surgery·Nikolaos G BaikoussisJohn Goudevenos
Dec 30, 2009·Hypertension·Kenichi SakakuraShin-ichi Momomura
Feb 24, 2010·The Journal of Thoracic and Cardiovascular Surgery·Santi TrimarchiUNKNOWN International Registry of Acute Aortic Dissection Investigators
Jul 14, 2010·Circulation·Alan C Braverman
Sep 15, 2010·Circulation·Santi TrimarchiUNKNOWN International Registry of Acute Aortic Dissection (IRAD) Investigators
Oct 30, 2010·Journal of the American College of Cardiology·Aaron M Ranasinghe, Robert S Bonser
Jan 8, 2011·The American Journal of Cardiology·Anna M BooherUNKNOWN International Registry of Acute Aortic Dissection (IRAD) Investigators
Oct 5, 2011·Circulation·Kevin M HarrisUNKNOWN International Registry of Acute Aortic Dissection (IRAD) Investigators
Mar 9, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tamenobu UedaUNKNOWN MAPPY Study Investigators

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Citations

Apr 23, 2013·Heart and Vessels·Pascal DelsartClaire Mounier-Vehier
Apr 24, 2015·International Heart Journal·Masaru SeguchiShin-ichi Momomura
Jun 4, 2014·Journal of Cardiac Surgery·Antonio SegretoFederico Bizzarri
Jan 30, 2014·Heart and Vessels·Kenshiro AraoShin-Ichi Momomura
Jul 22, 2016·Nature Reviews. Disease Primers·Christoph A NienaberJohn Pepper

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