Utility of melatonin to treat surgical stress after major vascular surgery--a safety study

Journal of Pineal Research
Bülent KücükakinIsmail Gögenur

Abstract

Surgery for abdominal aortic aneurysm is associated with elevated oxidative stress. As an antioxidant in animal and human studies, melatonin has the potential of ameliorating some of this oxidative stress, but melatonin has never been administered to adults during surgery for the purpose of reducing oxidative damage. The aim of this pilot study was to evaluate the safety of various doses of melatonin administered during or after surgery and to monitor the changes in biomarkers of oxidative stress and inflammation during the pre-, intra-, and postoperative period. Six patients undergoing aortic surgery received 10 (n = 2), 30 (n = 2) or 60 (n = 2) mg melatonin intravenously in the intraoperative phase and 10 mg orally for three nights after surgery. Patients were monitored for hemodynamic parameters during and after surgery. Any unexpected events during the hospitalization were registered. Blood samples were collected preoperatively and at 5 min, 6 hr and 24 hr after clamp removal or after re-circulation of the first leg and the samples were analyzed for malondialdehyde (MDA), ascorbic acid (AA), dehydroascorbic acid (DHA), and interleukin-6 (IL-6). Troponin I (TpI) and C-reactive protein (CRP) were also measured for 4 days afte...Continue Reading

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Citations

Sep 10, 2013·Saudi Journal of Anaesthesia·Souvik MaitraPuneet Khanna
Mar 10, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Bülent KücükakinIsmail Gögenur
Dec 22, 2011·Mutation Research. Reviews in Mutation Research·Russel J ReiterDun-Xian Tan
Aug 28, 2009·Journal of Pineal Research·Gu-Jiun LinHuey-Kang Sytwu
Jul 2, 2011·Journal of Pineal Research·Francisco A García-GilJoaquín J García
May 27, 2015·European Journal of Clinical Pharmacology·Nathja Groth HarpsøeJacob Rosenberg
Jul 20, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B KücükakinI Gögenur
Jun 4, 2013·International Journal of Molecular Sciences·Gu-Jiun LinHuey-Kang Sytwu
Dec 12, 2018·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Juyi ZhangJuan Yang
Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Russel J ReiterDan-Xian Tan
Sep 14, 2020·Molecular Biology Reports·Ahmet Ozer SehirliNedime Serakinci
Dec 2, 2020·Diseases·Daniel P CardinaliSeithikurippu R Pandi-Perumal
Apr 2, 2021·Oxidative Medicine and Cellular Longevity·Margarita Segovia-RoldanEsther Pueyo
May 7, 2021·Journal of Pineal Research·Su Jung HwangHyo-Jong Lee

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