Utility of molecular genetic signatures in the delineation of gastric neoplasia

Cancer
Mark KiddMichelle N Zikusoka

Abstract

Current techniques to define gastric neoplasia are limited but molecular genetic signatures can categorize tumors and provide biological rationale for predicting clinical behavior. We identified three gene signatures: Chromogranin A (CgA), MAGE-D2 (adhesion), and MTA1 (metastasis) that define gastrointestinal (GI) carcinoids and hypothesize that their expression can delineate gastric neoplasia. This strategy provides a molecular basis to define neuroendocrine gastric carcinoids (GCs), neuronal stromal tumors (GISTs), or epithelial cell (gastric adenocarcinomas [GCAs])-derived tumors. Total RNA was isolated from 38 GCs: Type I/II (n = 7), Type III/IV (n = 6), GISTs (n = 12), GCAs (n = 13), and normal mucosa (n = 12). Quantitative reverse transcriptase polymerase chain reaction (Q RT-PCR) gene expression was quantified against glyseraldehyde-3-phosphate dehydrogenase (GAPDH) and CgA and MTA1 protein expression levels were analyzed by immunohistochemical analyses of a gastric neoplasia microarray. CgA was elevated in Type I/II (10-fold; P < .01) and Type III/IV (100-fold, P < .005), decreased in GISTs (100-fold, P < .03), and unchanged in GCAs. MAGE-D2 was 5-10-fold elevated (P < .05) in Type III/IV, GISTs, and GCAs but not in Typ...Continue Reading

References

Aug 1, 1991·British Journal of Cancer·V SundaresanN M Bleehen
Jul 9, 1993·International Journal of Cancer. Journal International Du Cancer·A P de BruïneF T Bosman
Sep 1, 1993·American Journal of Clinical Pathology·P M PourK Kazakoff
Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·Y TohK Sugimachi
Aug 5, 1998·Cancer·H L WaldumJ M Polak
Nov 24, 1999·Journal of Clinical Pathology·W M Wong, N A Wright
Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·R L CampD L Rimm
Aug 22, 2001·Internal Medicine Journal·A Boussioutas, D Taupin
Aug 30, 2001·Surgical Oncology·K F BeckerH Hoefler
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Apr 30, 2003·Journal of Clinical Pathology·T TornóczkyL Pajor
Aug 19, 2003·Seminars in Surgical Oncology·Frederick L Greene
Aug 30, 2003·Surgical Oncology·Irvin M ModlinMark Kidd
Sep 30, 2003·The British Journal of Surgery·E M ConnollyJ V Reynolds
Feb 12, 2004·Cancer Research·Matthias D HoferMark A Rubin
Feb 20, 2004·Cancer Research·Sibele I MeirelesLuiz F L Reis
Mar 19, 2004·Pathology Oncology Research : POR·Funda ErenBahadir Güllüoğlu
Apr 20, 2004·International Journal of Cancer. Journal International Du Cancer·Yasushi TohGarth L Nicolson
Aug 7, 2004·Seminars in Oncology·Eddie K Abdalla, Peter W T Pisters
May 12, 2005·Gastroenterology·Irvin M ModlinMichael D Shapiro
May 17, 2005·Journal of Surgical Oncology·Michael C Heinrich, Christopher L Corless

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Citations

Jan 29, 2011·Langenbeck's Archives of Surgery·Simon SchimmackIrvin M Modlin
Sep 27, 2006·Pituitary·Eva Hofsli
Nov 29, 2007·Endocrine Pathology·Irina A Lubensky, Zhengping Zhuang
Jun 24, 2006·Annals of Surgery·Irvin M ModlinRobert L Camp
Nov 5, 2011·Gut·John K RamageUNKNOWN UK and Ireland Neuroendocrine Tumour Society
Nov 16, 2014·Cancer Metastasis Reviews·Jian LiuHaili Qian
Nov 2, 2014·Cancer Metastasis Reviews·Yasushi Toh, Garth L Nicolson
Nov 7, 2014·Cancer Metastasis Reviews·Ekjot KaurShilpee Dutt
Oct 25, 2014·Cancer Metastasis Reviews·Zhifeng NingHao Zhang
Apr 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Irvin M ModlinGeeta Eick
Apr 16, 2013·Best Practice & Research. Clinical Gastroenterology·Dermot O'TooleRobert T Jensen
Oct 19, 2012·Digestive Surgery·David A CrosbyJohn V Reynolds
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddS M Mane
Apr 26, 2007·Physiological Genomics·Mark KiddIrvin Modlin
Dec 12, 2019·Khirurgiia·A V AlekberzadeF Azari
Jan 18, 2019·Neuroendocrinology·Anna MalczewskaJaroslaw Ćwikła

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