Utility of N terminal pro brain natriuretic peptide in elderly patients

Postgraduate Medical Journal
R SivakumarS A Khan

Abstract

To evaluate the utility of N terminal pro brain natriuretic peptide (NT-proBNP) as a diagnostic marker for diastolic dysfunction or failure, systolic dysfunction, and significant valve disorders in patients over 75 years. Cohort study. Outpatient echocardiography service in a district general hospital. 100 consecutive patients. Sensitivity, specificity, positive predictive values, negative predictive values, and area under receiver operating characteristic curve for NT-proBNP assay in the diagnosis of left ventricular diastolic dysfunction or failure, systolic dysfunction, and significant valve disorders. For diagnosis of systolic dysfunction NT-proBNP level of 424 pg/ml had a sensitivity of 96%, specificity of 45%, positive predictive value of 36%, and negative predictive value of 96%. The area under the curve was 0.71 (95% confidence intervals: 0.69 to 0.89). In valve heart disease, level of 227 pg/ml had sensitivity of 91%, specificity of 43%, positive predictive value of 40%, and negative predictive value of 92%. Patients with diastolic dysfunction/failure had lower plasma concentrations. This study showed that NT-proBNP had excellent negative predictive value for systolic dysfunction and significant valve disorders in very...Continue Reading

References

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Citations

Jul 19, 2013·European Heart Journal·Britta VogelBenjamin Meder
Jun 17, 2008·The American Journal of the Medical Sciences·Kasper IversenHenrik Nielsen
Sep 29, 2007·Archives of Gerontology and Geriatrics·Joost H W RuttenAnton H van den Meiracker

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