Utility of Nonhuman Primates in Substance Use Disorders Research

ILAR Journal
Matthew L BanksSidney S Negus

Abstract

Substance use disorders (i.e., drug addiction) constitute a global and insidious public health issue. Preclinical biomedical research has been invaluable in elucidating the environmental, biological, and pharmacological determinants of drug abuse and in the process of developing innovative pharmacological and behavioral treatment strategies. For more than 70 years, nonhuman primates have been utilized as research subjects in biomedical research related to drug addiction. There are already several excellent published reviews highlighting species differences in both pharmacodynamics and pharmacokinetics between rodents and nonhuman primates in preclinical substance abuse research. Therefore, the aim of this review is to highlight three advantages of nonhuman primates as preclinical substance abuse research subjects. First, nonhuman primates offer technical advantages in experimental design compared to other laboratory animals that afford unique opportunities to promote preclinical-to-clinical translational research. Second, these technical advantages, coupled with the relatively long lifespan of nonhuman primates, allows for pairing longitudinal drug self-administration studies and noninvasive imaging technologies to elucidate th...Continue Reading

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Citations

Jan 16, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew L Banks
Apr 11, 2019·Journal of Medical Primatology·Lisa M Wooldridge, Brian D Kangas
Sep 14, 2018·Behavioural Pharmacology·Kathryn L SchwienteckMatthew L Banks
Aug 22, 2020·Psychopharmacology·Alison G P WakefordLeonard L Howell
May 24, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E Andrew Townsend
Jun 7, 2020·International Journal of Molecular Sciences·Xiao ZhangEric J Vallender
Jul 15, 2018·Neuroinformatics·Kurt G SchillingAdam W Anderson
Apr 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha O BrownCharles W Bradberry
Jul 21, 2021·Life Sciences in Space Research·Rajeev I DesaiCharles L Limoli

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