Utility of postoperative CEA for surveillance of recurrence after resection of primary colorectal cancer

International Journal of Surgery
Imran BhattiGiuseppe Garcea

Abstract

To evaluate the usefulness of postoperative CEA levels in the surveillance of colorectal cancer patients. Over a 56 month period a total of 569 patients with measured CEA levels underwent curative resection for colorectal cancer. The median follow up was 40 months, during which period recurrence occurred in 149. Serum CEA levels were measured at 6 monthly intervals starting from 3 months post resection. ROC was used to calculate the optimum cut-off of CEA (5 ng/ml). Postoperative elevation of CEA levels were more frequent in patients with an aggressive primary colorectal cancer (grade, T stage and nodal disease; p < 0.05). In patients found to have colorectal recurrence, a significantly higher proportion of patients were resectable in the group with a non-elevated CEA (diagnosed by CT with PET imaging p < 0.05). The median interval between CEA elevation and diagnosis of recurrence (diagnostic interval) was 4 weeks. CEA elevation led to a change in the routine surveillance program by bringing imaging forward by 2 months. CEA levels were a significant predictor of survival following resection of colorectal primary (CEA ≤5-38 months, CEA >5-27 months; p < 0.05). CEA (p < 0.05) retained its significance on multivariate analysis alo...Continue Reading

References

Sep 1, 1965·The Journal of Experimental Medicine·P Gold, S O Freedman
Aug 25, 1993·JAMA : the Journal of the American Medical Association·C G MoertelC Tangen
Jul 20, 1999·Diseases of the Colon and Rectum·L A Carriquiry, A Piñeyro
Aug 23, 2006·Future Oncology·Derek A O'Reilly, Graeme J Poston
Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emanuela FlaminiDino Amadori
Feb 20, 2007·World Journal of Surgery·S JonasP Neuhaus
Jul 16, 2011·Nuclear Medicine Communications·Bhagwant Rai MittalRajesh Gupta

❮ Previous
Next ❯

Citations

Aug 11, 2020·Journal of the Chinese Medical Association : JCMA·Chih-Sheng HuangShung-Haur Yang
Dec 16, 2018·International Journal of Molecular Sciences·Toni NunesAnne Janin
Feb 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guofen SongDi Zhang
Jan 19, 2021·Annals of Surgical Treatment and Research·Hyun Ryung KimBo Young Oh
Dec 1, 2020·World Journal of Gastrointestinal Oncology·Hiroaki ItoYumi Kamijo
Oct 17, 2021·Langenbeck's Archives of Surgery·Anand Ebin ThomasAvanish Saklani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.