Utility of pyrosequencing for rapid detection of tubercular meningitis (TBM) and associated susceptibility directly from CSF specimens

Tuberculosis
Kanchan AjbaniCamilla Rodrigues

Abstract

Tubercular meningitis (TBM) is a serious form of tuberculosis (TB). The diagnosis of TBM & susceptibility/resistance is difficult as TB MGIT culture lacks sensitivity & timeliness. Timely and accurate diagnosis of the TBM is the need of the hour for initiation of appropriate therapy. We have exploited pyrosequencing to detect TB and associated Multi/extensively drug resistant (MDR/ XDR-TB) directly from Cerebrospinal Fluid (CSF) specimens.

Citations

Dec 6, 2019·Indian Journal of Pediatrics·Himani BhasinSuvasini Sharma
May 2, 2019·Neurology. Clinical Practice·Jerome H Chin
Jan 16, 2020·The Indian Journal of Medical Research·Ravindra Kumar Garg
Aug 26, 2020·Current HIV/AIDS Reports·Kiran T Thakur
Jan 16, 2021·The Cochrane Database of Systematic Reviews·Mikashmi KohliKaren R Steingart
Sep 12, 2021·Neurology India·Kusum SharmaMarie Claire Rowlinson

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