Utility of QuantiFERON-TB Gold In-Tube assay in adult, pulmonary and extrapulmonary, active tuberculosis diagnosis

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Mohammed AzghayJérôme Stirnemann

Abstract

Tuberculosis remains a public health problem in France and the diagnosis of tuberculosis disease (TB) is sometimes difficult. The aim of this study was to analyse the contribution of the QuantiFERON-TB Gold In-Tube assay (QFT-GIT) to TB diagnosis. Sixty patients hospitalized with TB, for whom a QFT-GIT assay had been performed between June 2008 and June 2011 at the University Hospital of Bondy in the north-east of Paris, were identified retrospectively. Clinical and laboratory data were collected. The sensitivity, specificity, predictive values, and likelihood ratios of the QFT-GIT were all calculated. Furthermore, the characteristics of patients testing positive were compared to those of patients testing negative, as well as the QFT-GIT values according to several different factors. The sensitivity of the QFT-GIT was 85% (95% confidence interval (CI) 0.73-0.92) and specificity was 73.3% (95% CI 0.68-0.78). The positive predictive value was 39.5% and the negative predictive value was 97.3%. The positive and negative likelihood ratios were 3.2 and 0.20, respectively. The prevalence of TB in this population was 15% (pre-test probability). After a positive test result, the probability of TB increased to 40% (post-positive probabil...Continue Reading

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Citations

Jun 9, 2017·Journal of Clinical Laboratory Analysis·Li Di, Yan Li
Jul 12, 2019·Journal of Clinical and Translational Hepatology·David C WuGeorge Y Wu
May 11, 2017·Zeitschrift für Rheumatologie·B Ehrenstein, C Brochhausen
Jan 14, 2017·Microbiology Spectrum·Jonathan M Hand, George A Pankey

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