Abstract
Tuberculosis remains a public health problem in France and the diagnosis of tuberculosis disease (TB) is sometimes difficult. The aim of this study was to analyse the contribution of the QuantiFERON-TB Gold In-Tube assay (QFT-GIT) to TB diagnosis. Sixty patients hospitalized with TB, for whom a QFT-GIT assay had been performed between June 2008 and June 2011 at the University Hospital of Bondy in the north-east of Paris, were identified retrospectively. Clinical and laboratory data were collected. The sensitivity, specificity, predictive values, and likelihood ratios of the QFT-GIT were all calculated. Furthermore, the characteristics of patients testing positive were compared to those of patients testing negative, as well as the QFT-GIT values according to several different factors. The sensitivity of the QFT-GIT was 85% (95% confidence interval (CI) 0.73-0.92) and specificity was 73.3% (95% CI 0.68-0.78). The positive predictive value was 39.5% and the negative predictive value was 97.3%. The positive and negative likelihood ratios were 3.2 and 0.20, respectively. The prevalence of TB in this population was 15% (pre-test probability). After a positive test result, the probability of TB increased to 40% (post-positive probabil...Continue Reading
References
Jan 5, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elsie Lee, Robert S Holzman
Apr 20, 2005·Clinics in Chest Medicine·Daniel Brodie, Neil W Schluger
Apr 25, 2006·Lancet·Giovanni FerraraLuca Richeldi
Apr 3, 2007·Infection·M PaiS Kalantri
Feb 12, 2008·Chest·Yoshihiro KobashiMikio Oka
Dec 17, 2008·Diagnostic Microbiology and Infectious Disease·Kyoung-Ho SongKang Won Choe
Dec 22, 2009·Chest·Roland DielAlbert Nienhaus
Apr 28, 2010·Lung·Yoshihiro KobashiMikio Oka
Sep 10, 2010·The New England Journal of Medicine·Catharina C BoehmeMark D Perkins
Feb 25, 2011·PloS One·Peter HorbyTran Hien Nguyen
Dec 24, 2011·PloS One·Cristy Ho, Sing-Hang Cheung
Jan 14, 2012·The European Respiratory Journal·Enrico TortoliDaniela M Cirillo
Oct 27, 2012·The Lancet Infectious Diseases·J Lucian DavisKaren R Steingart
Jun 26, 2013·The Journal of Infection·You La JeonHee Joo Lee
Jul 10, 2013·BMC Infectious Diseases·Andrew D KerkhoffStephen D Lawn
Apr 11, 2014·Scandinavian Journal of Infectious Diseases·Magali BrierePascale Bemer
Citations
Jun 3, 2014·BMC Infectious Diseases·Manish RathiVinay Sakhuja
Mar 10, 2012·PloS One·Miguel SantinDavid Rigau
Aug 25, 2016·Tuberculosis·Megha SharmaArvind Rajwanshi
Jun 9, 2017·Journal of Clinical Laboratory Analysis·Li Di, Yan Li
May 30, 2019·Health Technology Assessment : HTA·Yemisi TakwoingiAjit Lalvani
Jan 29, 2020·Acta Paediatrica·Rutger BennetMargareta Eriksson
Jul 12, 2019·Journal of Clinical and Translational Hepatology·David C WuGeorge Y Wu
May 11, 2017·Zeitschrift für Rheumatologie·B Ehrenstein, C Brochhausen
Apr 12, 2017·Laboratory Medicine·You La JeonSo Young Kang
Jan 14, 2017·Microbiology Spectrum·Jonathan M Hand, George A Pankey