Utility of Rapid Influenza Molecular Testing in an Outpatient Hemodialysis Unit: A Prospective Cohort Study

Canadian Journal of Kidney Health and Disease
Matthew KadatzC F Lowe

Abstract

Early initiation of antiviral therapy for individuals at risk for severe influenza infection is important for improving patient outcomes. Current guidelines recommend empiric antiviral therapy for patients with end-stage kidney disease presenting with suspected influenza infection. Rapid molecular influenza assays may reduce diagnostic uncertainty and improve patient outcomes by providing faster diagnostics compared to traditional batched polymerase chain reaction (PCR) testing. To determine the utility of implementing a rapid influenza PCR assay compared to the standard of care in a hemodialysis unit. This is a prospective cohort study. A hospital-based dialysis unit in a tertiary care hospital. Adult patients with end-stage kidney disease on intermittent hemodialysis. Patient characteristics, influenza PCR swab results, antibiotic prescriptions, antiviral prescriptions, emergency room visits and hospitalizations. From November 1, 2017 to March 31, 2018, we assigned samples collected from a single center, hemodialysis unit to be processed using a rapid influenza PCR (cobas® Influenza A/B & respiratory syncytial virus assay) or the standard of care (in-house developed multiplex PCR). Samples were assigned to the rapid PCR if th...Continue Reading

References

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Sep 2, 2018·The Journal of Hospital Infection·C F LoweUNKNOWN Providence Health Care Infection Prevention and Control Team

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BETA
PCR

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