Utility of serological biomarkers for giant cell arteritis in a large cohort of treatment-naïve patients

Clinical Rheumatology
Blaž BurjaAlojzija Hočevar

Abstract

Early diagnosis and treatment of giant cell arteritis (GCA) is crucial for preventing ischemic complications. Multiple serological markers have been identified; however, there is a distinct lack of predicting markers for GCA relapse and complications. Our main objective was to identify serological parameters in a large cohort of treatment-naïve GCA patients, which could support clinicians in evaluating the course of the disease. Clinical data was gathered, along with analyte detection using Luminex technology, ELISA, and nephelometry, among others. Unsupervised hierarchical clustering and principal component analysis of analyte profiles were performed to determine delineation of GCA patients and healthy blood donors (HBDs). Highest, significantly elevated analytes in GCA patients were SAA (83-fold > HBDs median values), IL-23 (58-fold), and IL-6 (11-fold). Importantly, we show for the first time significantly changed levels of MARCO, alpha-fetoprotein, protein C, resistin, TNC, TNF RI, M-CSF, IL-18, and IL-31 in GCA versus HBDs. Changes in levels of SAA, CRP, haptoglobin, ESR, MMP-1 and MMP-2, and TNF-alpha were found associated with relapse and visual disturbances. aCL IgG was associated with limb artery involvement, even foll...Continue Reading

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Citations

Mar 28, 2019·Rheumatology·Sabine AdlerPeter M Villiger
Dec 14, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Alfredo Sadun, Lynn Gordon
Mar 14, 2020·Current Opinion in Rheumatology·Naomi Serling-Boyd, John H Stone
May 31, 2020·Clinical Rheumatology·Patrícia MartinsCristina Ponte
Oct 1, 2019·Rheumatic Diseases Clinics of North America·Dario CamellinoEric L Matteson
Feb 12, 2021·Current Rheumatology Reports·Enrico TombettiDario Camellino
Mar 9, 2021·Frontiers in Immunology·Iva Sorić HosmanLovro Lamot
Nov 18, 2019·Autoimmunity Reviews·Anais DartevelLaurence Bouillet

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