Utility of serum ratio of heart-type fatty acid-binding protein to myoglobin for cardiac damage regardless of renal dysfunction

Circulation Journal : Official Journal of the Japanese Circulation Society
Masato FuruhashiKazuaki Shimamoto

Abstract

The serum ratio of heart-type fatty acid-binding protein to myoglobin (F/M) has been shown to be a new marker for cardiac damage and volume overload in hemodialysis patients. We evaluated the utility of F/M in hemodialysis patients compared to control subjects. Twenty-one hemodialysis patients and 17 control subjects with normal renal function were investigated. Using a cutoff point of mean + 2SD of the F/M in the controls (value: 0.147), the hemodialysis patients were divided into 2 groups. The concentrations of atrial natriuretic peptide (ANP) and brain natriuretic peptide after hemodialysis in the high F/M group were higher than those in the low F/M group. The mean level of ANP in the low F/M group was almost the upper limit of normal range. The values of left ventricular end-diastolic dimension and left ventricular mass index in the high F/M group were higher than those in the low F/M group, and the mean levels of those in the low F/M group were almost the same as those in the controls. The F/M can be evaluated by the absolute value regardless of renal dysfunction, and the value of 0.147 might be useful for determining the cutoff level of cardiac involvement.

References

Jan 1, 1989·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K M LeunissenJ P van Hooff
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Jun 1, 1995·Journal of the American Society of Nephrology : JASN·R N FoleyP E Barré
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliLorenzo Salvatore Malatino
Jan 28, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiko SeinoUNKNOWN Tokyo Rapid-Test Office Cardiologists (Tokyo-ROC) Study

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Citations

Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi NiizekiIsao Kubota
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Jun 7, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong LiuHua Jing
Jan 9, 2021·Clinical Chemistry·David CollisterMichael Walsh

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