Utility of the Beck Depression Inventory to screen for and track depression in injection drug users seeking hepatitis C treatment.

General Hospital Psychiatry
Paul E HoltzheimerPeter Roy-Byrne

Abstract

Treating acute hepatitis C (HCV) in injection drug users (IDUs) is complicated by a high prevalence of psychiatric comorbidities that may lead to increased risk for depressive complications of interferon treatment. Effective screening strategies are needed to help non-psychiatric clinicians identify depressive disorders. Thirty IDUs with acute HCV completed the Beck Depression Inventory (BDI), underwent a psychiatric examination, and were randomized to 24 weeks of pegylated interferon treatment (IFA) or observation (OBS). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of the BDI for diagnosing depression (with a cutoff >10) were calculated. The psychiatrist's diagnosis was used as the gold standard. Depression severity was assessed over time with the BDI. Forty-seven percent of individuals met criteria for a depressive disorder. Sensitivity (91%) and NPV (92%) were high for the BDI; specificity (58%) and PPV (56%) were low. BDI worsened in 2 patients completing the study (one IFA, one OBS); two IFA patients were discontinued for possible depression-related complications. At baseline, subject-rated fatigue was associated with alanine aminotransferase level. The BDI is an adequate tool for ruling ou...Continue Reading

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Citations

Apr 4, 2013·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Jennifer BrownGeorge Benson
Apr 30, 2013·Postgraduate Medical Journal·Jefferson AbrantesCarlos Eduardo Brandão de Mello
Oct 18, 2011·General Hospital Psychiatry·Bruno Cópio FábregasAntônio Lúcio Teixeira
Apr 19, 2011·The Journal of the Association of Nurses in AIDS Care : JANAC·Alice AsherKimberly Page
Jun 18, 2014·Scandinavian Journal of Infectious Diseases·Lone W MadsenPeer B Christensen
Jul 17, 2012·Journal of Hepatology·Behzad HajarizadehGregory J Dore
Jun 20, 2020·European Journal of Gastroenterology & Hepatology·Amal Tohamy Abdel MoezAmira Mahmoud Al Balakosy

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