Utility of the CKD273 peptide classifier in predicting chronic kidney disease progression

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Elena Critselis, H J Lambers Heerspink

Abstract

Chronic kidney disease (CKD) is a growing public health concern, afflicting approximately one-tenth of adults in developed countries. However, the clinical need for an accurate test, such as a biomarker and/or peptide classifier, for predicting CKD progression and related adverse outcomes remains unaddressed. Recently, a proteomics approach based on capillary electrophoresis-mass spectrometry was employed to develop a urinary peptide-based high-dimensional classifier, namely CKD273, for predicting CKD progression. The study aims to critically appraise the evidence level of the CKD273 classifier's utility in predicting CKD progression, according to the Oxford Evidence-Based Medicine (EBM) and Strength of Recommendation Taxonomy (SORT) guidelines. Eligible studies were identified by a literature search of MEDLINE and Web of Science Expanded Core Collection databases. Limitations were set to prospective cohort studies evaluating the classifier's accuracy in predicting CKD progression. Data extraction was undertaken according to a predefined protocol by two independent reviewers. The EBM and SORT guidelines were applied to appraise the CKD273 classifier's utility for predicting CKD progression. The query search results rendered fou...Continue Reading

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Feb 18, 2016·Kidney International·Julie KleinJoost P Schanstra
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