PMID: 7023311Sep 1, 1981Paper

Utility of the fluorescent antinuclear antibody test in a single patient

Annals of Internal Medicine
B Richardson, W V Epstein

Abstract

The literature on the fluorescent antinuclear antibody (FANA) test, commonly used in diagnosing systemic lupus erythematosus, was analyzed. The specificity of the test reported in early descriptive studies is much greater than the value obtained when the test is used in clinical practice. The probability of systemic lupus erythematosus in a specific patient was determined when different numbers of the classification criteria developed by the American Rheumatism Association are present. The predictive value of a positive or negative FANA test result was calculated using different pretest probabilities based on clinical criteria. The marginal benefit of the FANA test was determined as minimal at points of very large and very small pretest probability of systemic lupus erythematosus, and as maximal when five clinical criteria are present.

Citations

Jul 13, 2002·Arthritis and Rheumatism·Qianjin LuBruce Richardson
Sep 1, 1988·Journal of General Internal Medicine·M J Lichtenstein, T Pincus
Aug 1, 1991·Acta Neurologica Scandinavica·B MichielsensH Carton
Feb 1, 1997·Baillière's Clinical Rheumatology·D L Scott
Jul 1, 1985·Clinics in Dermatology·K B Kulick, M Reichlin
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Sep 17, 1998·Journal of the American Academy of Dermatology·S R PetersonM Duvic
Jul 22, 2014·Vaccine·Sang Beom HanHee Kyung Yang
Apr 1, 1984·Arthritis and Rheumatism·C D SmithN F Rothfield
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Dec 1, 1983·Arthritis and Rheumatism·D M Skillrud, T W Bunch
Aug 1, 2000·Hospital Practice·H L Fred
Feb 28, 1983·Life Sciences·R S SurwitM Duvic

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