Utility of the New Indian Society of Paediatric and Adolescent Endocrinology (ISPAE) Guidelines for Congenital Hypothyroidism Screening in a High Risk Unit.

Indian Journal of Pediatrics
Lakshmi VenugopalanR Shanmughasundaram

Abstract

To study the new ISPAE guidelines in neonates with congenital hypothyroidism and present authors' experience in managing these neonates. A retrospective review of all babies who were screened for congenital hypothyroidism in the institution over a period of 5 y was conducted. Details pertaining to maternal risk factors, neonatal risk factors, screening TSH, venous TSH and details of etiological evaluation including: ultrasound thyroid, technetium 99m scintigraphy and anti thyroid peroxidase antibody estimation were retrieved. The cases were assessed using the new ISPAE guidelines. During the study period, 8107 babies were screened for congenital hypothyroidism, 83 cases had confirmed disease and 47 had established etiology. There is a fair correlation between screening TSH and venous TSH (r = 0.7, p < 0.05). The estimated incidence of congenital hypothyroidism in present series is 1 in 97 cases. Out of the 83 cases, 36 (43.3%), 16 (19.2%) and 31 (37.3%) cases had screening TSH >20 μIU/mL, 6-20 μIU/mL and < 6 μIU/mL, respectively. Out of the 47 babies with screening TSH <20 μIU/mL, 23 (48.9%), 25 (53.1%) and 12 (25.5%) cases had prematurity, maternal thyroid disease and illness, respectively, as risk factors (some babies had mor...Continue Reading

References

Apr 1, 2004·Indian Journal of Pediatrics·A Radha Rama Devi, S M Naushad
Feb 19, 2011·Journal of Inherited Metabolic Disease·Sunita BijarniaVeronica C Wiley
Feb 28, 2013·The Journal of Clinical Endocrinology and Metabolism·Antonella OlivieriUNKNOWN Italian Study Group for Congenital Hypothyroidism
Jan 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Juliane LégerUNKNOWN Congenital Hypothyroidism Consensus Conference Group
Feb 4, 2014·Medicina clínica·M Carmen Temboury MolinaSusana Ares Segura
Feb 13, 2014·The Journal of Pediatrics·Maria Cristina VigoneGiovanna Weber
Sep 18, 2014·Indian Pediatrics·Vignesh GopalakrishnanVijayalakshmi Bhatia
May 18, 2016·Indian Journal of Endocrinology and Metabolism·Sheetal G LakshminarayanaLakshminarayana R Gopaliah
Aug 30, 2018·Hormone Research in Pædiatrics·Giovanni PreziosoFrancesco Chiarelli

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Citations

Sep 22, 2021·Indian Journal of Pediatrics·Anurag Bajpai

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