Utility of the quasi-monomorphic variation range in unresectable metastatic colorectal cancer patients

Cancer Science
Hideaki BandoTakayuki Yoshino

Abstract

Microsatellite Instability (MSI) status is an established predictive biomarker for the treatment of the anti-programmed death 1 (PD-1) antibody. The current approach to determine the MSI status in tumours requires matched normal DNA. Some mononucleotide microsatellite markers are known to have few variant alleles in both Caucasians and Asians. Therefore, the length of these microsatellite makers is almost confined within the quasi-monomorphic variation range (QMVR). Considering the application of MSI testing for various types of cancers, a simple, sensitive and inexpensive method is desired. This study assessed the clinical utility of the QMVR for determining the MSI status in patients with unresectable metastatic colorectal cancer (mCRC). The study enrolled 435 patients with mCRC. The concordance of the MSI status in mCRC between the standard method using tumour DNA plus matched normal DNA and the testing method using only tumour DNA was evaluated. Eleven (2.5%) MSI-high cases were detected by both the standard and testing methods. The sensitivity and specificity of the testing method were both 100%, indicating complete concordance between the methods. Among the mononucleotide markers, three and two patients showed discordance...Continue Reading

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Citations

Jan 8, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kanako KurataMasafumi Nakamura
Aug 15, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hourin ChoKokichi Sugano
Sep 15, 2020·JCO Precision Oncology·Hiromichi Ebi, Hideaki Bando
Dec 30, 2021·Pediatric Hematology and Oncology·Taro YoshidaYoshiyuki Takahashi

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

GeneMapper

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