Utility of the WHO neurobehavioral core test battery in Chinese workers-a meta-analysis

Environmental Research
Wei ZhouDavid C Christiani

Abstract

We performed a meta-analysis to determine the most sensitive subtests of the WHO Neurobehavioral Core Test Battery (NCTB) when administered to Chinese workers. Extensive Chinese Biological Medical Database and MEDLINE searches, review of cited references, and discussion with other investigators were undertaken. Data were extracted from 39 eligible studies; the summary effects (effect sizes) were calculated using a fixed-effect model. Various exposure agents showed different sensitivities to the seven subtests of NCTB. For mercury-exposure, the Benton Visual Retention was the most sensitive subtest, with an effect size (95% CI) of 6.0 (4.4-7.6). For lead-exposure, the most sensitive subtests were the Pursuit Aiming II and Profile of Mood States, with effect sizes (95% CI) of 11.3 (8.3-14.3) and 10.6 (7.5-13.7), respectively. For organic solvents-exposure, Digit Span, Pursuit Aiming II, and Digit Symbol were the most sensitive subtests, with effect sizes (95- CI) of 4.7 (3.3-6.1), 4.6 (3.1-6.1), and 4.1 (2.7-5.5), respectively.

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Citations

Feb 22, 2008·Environmental Health Perspectives·Kao-Chang LinYueLiang Leon Guo
Sep 4, 2004·Environmental Health Perspectives·Gaku IchiharaYasuhiro Takeuchi
Dec 17, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kao-Chang LinDer-Shin Ke
Sep 13, 2005·Journal of Occupational and Environmental Medicine·Shun-Sheng ChenShung-Lon Lai
Dec 15, 2005·Public Health Reports·Basema SaddikDeborah Black
Jul 9, 2021·The Clinical Neuropsychologist·Christopher M NguyenDaryl Fujii

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