Utility of Transient Elastography in Estimating Hepatic Iron Concentration in Comparison to Magnetic Resonance Imaging in Patients Who are Transfusion-Dependent: A Canadian Center Experience

Hemoglobin
George OuHatoon Ezzat

Abstract

Transfusion-dependent hereditary anemias such as β-thalassemia (β-thal), predispose patients to iron overload and its numerous clinical sequelae. Accurate assessment of overall iron status and prompt initiation of chelation therapy to prevent irreversible end-organ damage can be achieved using magnetic resonance imaging (MRI) to measure liver iron concentration (LIC) as a surrogate marker of total body iron; however, its access may be associated with long wait times and delay in treatment. We report an observational cohort study at a single tertiary care center assessing the theoretical role of transient elastography (TE), which measures liver stiffness, in estimating LIC compared to other established diagnostic measures. While regression analyses confirm a moderate correlation between LIC per R2 MRI and serum ferritin level (pooled estimate of correlation = 0.55), there was no significant correlation between TE reading and LIC based on R2 MRI (pooled estimate of correlation = -0.06), and only a weak correlation was observed with serum ferritin level (pooled estimate of correlation = 0.45). These results suggest TE may not be sensitive enough to detect subtle changes in the hepatic parenchymal stiffness associated with liver ir...Continue Reading

References

Sep 1, 1994·The New England Journal of Medicine·N F OlivieriA R Cohen
Aug 1, 1996·Journal of Hepatology·J P VilleneuveM Lefebvre
Aug 3, 2000·The New England Journal of Medicine·E AngelucciG Lucarelli
Apr 24, 2003·Journal of the Air & Waste Management Association·Anthony HamlettRuss Wolfinger
Feb 28, 2004·Blood·Melody J CunninghamUNKNOWN Thalassemia Clinical Research Network
Apr 9, 2004·Lancet·Y GandonY Deugnier
Apr 28, 2004·Cell·Matthias W HentzeNancy C Andrews
Sep 16, 2005·The New England Journal of Medicine·Deborah Rund, Eliezer Rachmilewitz
Aug 22, 2007·Pediatric Radiology·Maria I Argyropoulou, Loukas Astrakas
Dec 18, 2007·European Journal of Haematology·Tristan MiraultChristian Rose
Mar 17, 2010·Clinical Drug Investigation·Giovan Battista RuffoRossana Tarantino
Apr 1, 2010·World Journal of Gastroenterology : WJG·Konstantinos Tziomalos, Vassilios Perifanis
Jul 27, 2010·American Journal of Hematology·Mirella FraquelliMaria Domenica Cappellini
Jan 12, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·V Ronique Loustaud-RattiArnaud Jaccard
Aug 16, 2012·Clinical and Molecular Hepatology·Kyu Sik Jung, Seung Up Kim
Jan 11, 2013·Pediatric Hematology and Oncology·Galila M MokhtarHeba T A Ali
Jul 4, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tim G St PierreAli Taher
Jan 24, 2014·Current Gastroenterology Reports·Alan Bonder, Nezam Afdhal
Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maria SarigianniApostolos Tsapas
Jul 30, 2014·Hematology/oncology Clinics of North America·John C Wood
Dec 17, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Ludivine LegrosDominique Guyader

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.