Utility of transmural myocardial strain profile for prediction of early left ventricular dysfunction in patients with Duchenne muscular dystrophy

The American Journal of Cardiology
Tetsushi YamamotoKen-ichi Hirata

Abstract

Myocardial damage in Duchenne muscular dystrophy (DMD) has lethal outcomes, making early detection of myocardial changes in patients with DMD vital, because early treatment can help prevent the development of myocardial fibrosis. The aim of the present study was, therefore, to test the hypothesis that transmural strain profile (TMSP) analysis can predict future left ventricular (LV) dysfunction in patients with DMD with preserved ejection fraction. We studied 82 consecutive patients with DMD without LV wall motion abnormality, with an ejection fraction of 60 ± 5% (all ≥55%) and age 11 ± 3 years. Echocardiography was performed at baseline and 1 year of follow-up. TMSP in the posterior wall was evaluated from the mid-LV short-axis view. A normal TMSP pattern (1 peak in the endocardium, group 1) was seen in 44 patients, and TMSP with a notch (2 peaks in the endocardium, group 2) in the remaining 38 (46%). Wall motion abnormality in the posterior wall was observed in 16 patients (42%) in group 2 at 1 year of follow-up but in none of the patients in group 1 (42% vs 0%; p <0.001). Importantly, multivariate analysis showed that only TMSP with a notch (odds ratios 1.524, p <0.001) was an independent determinant of the presence of LV po...Continue Reading

References

Apr 30, 1999·American Heart Journal·Y IshikawaR Minami
Feb 18, 2003·Cardiology·Josef Finsterer, Claudia Stöllberger
May 7, 2003·Journal of Child Neurology·Francesco Muntoni
Jul 18, 2006·International Journal of Cardiology·Hitoko OgataRyoji Minami
Apr 15, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Luc MertensGunnar Buyse
Nov 28, 2008·International Journal of Cardiology·A Fayssoil

❮ Previous
Next ❯

Citations

Apr 25, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Christopher F SpurneyPaula R Clemens
Feb 15, 2018·Muscle & Nerve·Raphael Henrique Déa CirinoClaudio Leinig Pereira da Cunha
Mar 17, 2017·The International Journal of Cardiovascular Imaging·Marco SparteraGiovanni La Canna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.