Utility of TTF-1 and Napsin-A in the work-up of malignant effusions

Diagnostic Cytopathology
Mohamed El HagC W Michael

Abstract

Similar to TTF-1, Napsin-A is recently used increasingly to differentiate between pulmonary adenocarcinoma (P-ADC) and extra-pulmonary adenocarcinoma (EP-ADC). The aim of this study was to compare the performance of TTF-1 and Napsin-A in determining the primary origin of adenocarcinoma in malignant serous effusion. Following IRB approval, cellblocks from 139 cases of malignant serous effusions of histologically or clinically determined origin including: 26 P-ADC, 108 EP-ADC, 2 pulmonary squamous cell carcinoma (P-SQC), and 3 pulmonary small cell carcinoma (P-SCC) were retrieved. Each case was stained with Napsin-A and TTF-1 and evaluated for positivity and intensity of staining. Napsin-A and TTF-1 stained positive in 17/26 (65%) and 14/26 (54%) of P-ADC and in 2/108 (1.8%) and 0/108 (0%) of EP-ADC with a PPV of 89 and 100%, respectively. In combination, they positively stained 18/26 (70%) of P-ADC with a PPV of 90%. Out of 9 poorly differentiated P-ADC, 7 (78%) stained positive for Napsin-A, while 4 (45%) were reactive for TTF-1. Both Napsin-A and TTF-1 were negative in P-SQC, while P-SCC reacted positively for TTF-1 in 2/3 (66%) of cases and none for Napsin-A. Napsin-A and TTF-1 are both useful markers in distinguishing P-ADC ...Continue Reading

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Citations

Mar 28, 2017·World Journal of Gastrointestinal Oncology·Kanthi Rekha BadipatlaHarish K Patel
Nov 16, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Marianne EngelsPinar Firat
May 1, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Rafael Martínez-Girón, Santiago Martínez-Torre
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Aug 7, 2018·British Journal of Cancer·Victoria El-KhouryYeoun Jin Kim
Mar 7, 2021·Diagnostic Cytopathology·Wadad S MneimnehClaire W Michael

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