Utility of Whole Genome Sequencing in Assessing and Enhancing Partner Notification of Neisseria gonorrhoeae Infection.

Sexually Transmitted Diseases
Ling Yuan KongMark H Wilcox

Abstract

Gonorrhea is a sexually transmitted infection of global concern. We investigated whole-genome sequencing (WGS) as a tool to measure and enhance partner notification (PN) in gonorrhea management. Between May and November 2018, all N. gonorrhoeae isolated from patients attending Leeds Sexual Health, United Kingdom, underwent WGS. Reports listing sequences within 20 single-nucleotide polymorphisms (SNPs) of study isolates within a database containing select isolates from April 1, 2016, to November 15, 2018, were issued to clinicians. The proportion of cases with a potential transmission partner identified by PN was determined from patient and PN data. The WGS reports were reviewed to identify additional cases within 6 SNPs or less and verified for PN concordance. Three hundred eighty isolates from 377 cases were successfully sequenced; 292 had traceable/contactable partners and 69 (18%) had a potential transmission partner identified by PN. Concordant PN and WGS links were identified in 47 partner pairs. Of 308 cases with no transmission partner by PN, 185 (60%) had a case within 6 SNPs or less; examination of these cases' PN data identified 7 partner pairs with previously unrecognized PN link, giving a total of 54 pairs; all had ...Continue Reading

References

Jul 2, 2014·Clinical Microbiology Reviews·Magnus Unemo, William M Shafer
Nov 26, 2015·Sexually Transmitted Infections·Stephanie A ChisholmHelen Fifer
Oct 30, 2016·The Lancet Infectious Diseases·Dilrini De SilvaDavid W Eyre
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·David W EyreJohn Paul
Sep 7, 2019·Nature Communications·Deborah A WilliamsonBenjamin P Howden
Dec 25, 2019·International Journal of STD & AIDS·Helen FiferMark FitzGerald

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