PMID: 4342167Feb 1, 1972

Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver

The Biochemical Journal
K O LindrosO A Forsander

Abstract

1. Removal of acetaldehyde and ethanol has been studied in perfused rat livers. 2. The maximum rate of ethanol oxidation was 2mumol/min per g of liver, which was less than the calculated capacity of the ethanol-oxidizing system. The lactate/pyruvate ratio of the medium increased with the rate of ethanol removal. At low ethanol concentrations most of the acetaldehyde formed was oxidized further, but at ethanol concentrations above 16mm about 60% of the acetaldehyde left the liver unmetabolized. 3. At lower concentrations the greater part of added acetaldehyde was oxidized, but above 5mm, 50-60% of that removed was recovered as ethanol. 4. When the reduction of acetaldehyde was blocked by pyrazole, removal was strongly diminished. There was no effect on the lactate/pyruvate ratio during oxidation of low concentrations of acetaldehyde, even in the presence of pyrazole, but at higher concentrations a gradual increase occurred. 5. The results indicate that during ethanol oxidation the ethanol/acetaldehyde pair is not in redox equilibrium with the lactate/pyruvate pair. Ethanol oxidation was abolished by addition of acetaldehyde. Under these conditions the lactate/pyruvate ratio was 1.5-1.8 times the ethanol/acetaldehyde ratio, indic...Continue Reading

Citations

Oct 1, 1974·European Journal of Biochemistry·T CronholmJ Sjövall
Jan 1, 1974·Annals of the New York Academy of Sciences·J BernsteinY Israel
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·H WeinerA J Pelletier
Apr 1, 1979·Archives of Biochemistry and Biophysics·A I Cederbaum, E Dicker
Feb 1, 1977·Archives of Biochemistry and Biophysics·A I Cederbaum, E Rubin
Feb 11, 1982·Biochemical and Biophysical Research Communications·L A VidelaA Valenzuela
Nov 1, 1974·Angewandte Chemie·H Sies
Jan 1, 1999·Addiction Biology·M E Quintanilla, L Tampier
Apr 1, 1983·Cell Biochemistry and Function·W J Jenkins, T J Peters
Feb 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·M L HannukselaM J Savolainen
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·C DelmasJ F Biellmann
Jul 1, 1980·Alcoholism, Clinical and Experimental Research·J MørlandL Svendsen
Jan 1, 1977·Alcoholism, Clinical and Experimental Research·E R Gordon
Jul 1, 1978·Bruxelles médical·J Casselman
Oct 1, 1980·Alcoholism, Clinical and Experimental Research·P K WilkinsonL O Wilkin
Oct 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shiguang LiuJaideep Behari
Jul 1, 1993·Diabetes/metabolism Reviews·A Avogaro, A Tiengo
Jan 1, 1976·Acta Pharmacologica Et Toxicologica·H Marchner, O Tottmar
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·C S Lieber
Jan 1, 1981·Evolution; International Journal of Organic Evolution·Douglas R Cavener, Michael T Clegg
Jun 1, 1982·Jinrui idengaku zasshi. The Japanese journal of human genetics·A Yoshida
Jan 1, 1975·Acta Pharmacologica Et Toxicologica·H I Thieden
Feb 20, 1975·The New England Journal of Medicine·N H Raskin

Related Concepts

Acetaldehyde
Alcohol Oxidoreductases
Ethanol
Lactate Dehydrogenase
Lactates
Liver
Mitochondria, Liver
NADH
Oxidation-Reduction
Perfusion

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