Utilization and Outcomes of Single and Dual Kidney Transplants from Older Deceased Donors in the United Kingdom.

Clinical Journal of the American Society of Nephrology : CJASN
Maria IbrahimChris J Callaghan

Abstract

Kidneys from elderly deceased donors are often discarded after procurement if the expected outcomes from single kidney transplantation are considered unacceptable. An alternative is to consider them for dual kidney transplantation. We aimed to examine the utilization of kidneys from donors aged ≥60 years in the United Kingdom and compare clinical outcomes of dual versus single kidney transplant recipients. Data from the United Kingdom Transplant Registry from 2005 to 2017 were analyzed. We examined utilization rates of kidneys retrieved from deceased donors aged ≥60 years, and 5-year patient and death-censored graft survival of recipients of dual and single kidney transplants. Secondary outcomes included eGFR. Multivariable analyses and propensity score analysis were used to correct for differences between the groups. During the study period, 7841 kidneys were procured from deceased donors aged ≥60 years, of which 1338 (17%) were discarded; 356 dual and 5032 single kidneys were transplanted. Donors of dual transplants were older (median, 73 versus 66 years; P<0.001) and had higher United States Kidney Donor Risk Indices (2.48 versus 1.98; P<0.001). Recipients of dual transplants were also older (64 versus 61 years; P<0.001) and...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jan 27, 2006·The New England Journal of Medicine·Giuseppe RemuzziUNKNOWN Dual Kidney Transplant Group
Mar 3, 2007·Clinical Chemistry·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jun 23, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Jesse ScholdHerwig-Ulf Meier-Kriesche
Aug 18, 2009·The Journal of Urology·Frank T D'ArcyDavid P Hickey
Feb 24, 2010·Transplantation·Susan V FuggleUNKNOWN Kidney Advisory Group of NHS Blood and Transplant
Feb 24, 2010·Transplantation·Rachel J JohnsonUNKNOWN Kidney Advisory Group of NHS Blood and Transplant
Jul 20, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B EkserP Rigotti
Dec 20, 2011·Transplantation·Christopher J E WatsonJ Andrew Bradley
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Fernández-LorenteJ M Cruzado
Sep 15, 2012·Transplantation Proceedings·M A FrutosD Hernández
Jun 21, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Elisa Sefora PierobonRigotti Paolo
Aug 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T KlairL K Kayler
Sep 5, 2013·BMJ Open·Christopher J CallaghanUNKNOWN UK Liver Transplant Audit
Dec 21, 2013·Transplantation·Rachel J JohnsonUNKNOWN UK Transplant Registry
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B TanrioverM A Hardy
Oct 10, 2014·Clinical Transplantation·Paolo RigottiLucrezia Furian
Feb 3, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V KosmoliaptsisG J Pettigrew
Mar 19, 2015·Kidney International·Dominic M SummersJ Andrew Bradley
Jun 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D H MallonG J Pettigrew
Nov 26, 2015·Transplantation·Maarten Naesens
Apr 26, 2016·Transplantation Proceedings·A MarianiL De Carlis
Sep 9, 2016·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Adam P JohnsonCataldo Doria
Oct 18, 2016·Transplantation·Renaud SnanoudjChristophe Legendre
Jul 29, 2017·International Scholarly Research Notices·Muhammad Abdul Mabood KhalilRabeea Azmat
Mar 25, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert M MerionDavid Collett
May 8, 2018·Kidney International·Sumit MohanDavid J Cohen
Oct 23, 2018·Clinical Transplantation·Matthew CooperStephen Pastan
Jan 11, 2019·Journal of the American College of Surgeons·Jeffrey RogersRobert J Stratta
Jan 13, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Benedict L PhillipsChris J Callaghan
May 6, 2019·Urology·Abhinav SethDeepesh Benjamin Kenwar
Nov 24, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Maria IbrahimDarren Stewart
Jan 4, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K IsraniB L Kasiske

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Citations

May 7, 2021·Nature Reviews. Nephrology·Raymond VanholderGabriel C Oniscu
Jun 11, 2021·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Omar Mobeen IsmailTitus Augustine

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