PMID: 9524222Apr 3, 1998Paper

Utilization of an 86 bp exon generates a novel adducin isoform (beta 4) lacking the MARCKS homology domain

Biochimica Et Biophysica Acta
J H SinardJ S Morrow

Abstract

A novel isoform of beta-adducin has been amplified and characterized from a human bone marrow cDNA library (GenBank #U43959). This isoform arises from the insertion of an 86 bp alternatively spliced and previously unrecognized exon (now termed exon 15) within codon 581 of the human red blood cell beta-adducin sequence. This results in an insertion of 28 novel amino acids. The remainder of the red cell beta-adducin mRNA is then translated in a different reading frame, adding an additional 35 novel amino acids prior to the stop codon. This new isoform, thus, replaces beta 1-adducin sequence after residue 580 with a total of 63 new amino acids. Sequences from genomic clones of the human beta-adducin gene show that this alternate exon is flanked by splice consensus sequences and is appropriately located in the genomic map between exons encoding up-stream and down-stream sequences, thus defining a new exon. The COOH-terminus of this new isoform, which we designate beta 4, lacks a 22 amino acid lysine-rich sequence common to both the human red cell alpha- and beta-adducin subunits and homologous to a highly conserved region in MARCKS, a filamentous actin-cross linking protein regulated by protein kinase C and calcium/calmodulin. beta...Continue Reading

References

Oct 1, 1991·The Journal of Cell Biology·S P KennedyJ S Morrow
Nov 1, 1991·The Journal of Cell Biology·R JoshiV Bennett
Aug 1, 1989·The Journal of Cell Biology·H W KaiserV Bennett
Jan 1, 1989·Cell Motility and the Cytoskeleton·T R ColemanJ S Morrow
Feb 1, 1989·American Journal of Hypertension·G BianchiP Pati
Nov 1, 1986·The Journal of Clinical Investigation·R AlejandroD H Mintz
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S SalardiG Bianchi
Jul 23, 1987·Nature·K Gardner, V Bennett
Aug 11, 1995·The Journal of Biological Chemistry·C A Hughes, V Bennett
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D DingH D Lipshitz
May 24, 1995·Biochimica Et Biophysica Acta·C NegriniB Kachar
Mar 1, 1995·Hypertension·G CasariF Macciardi
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·G BianchiM Ferrandi
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J Grumont, S Gerondakis
Oct 1, 1993·Molecular Immunology·A Rinfret, S K Anderson
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A Scaramuzzino, J S Morrow
Apr 5, 1996·The Journal of Biological Chemistry·P A KuhlmanV M Fowler
Jun 7, 1996·The Journal of Biological Chemistry·R T PremontJ Hanoune
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·G BianchiB R Barber
Jul 15, 1997·Genomics·D M GilliganA Silberfein

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Citations

Sep 3, 2003·Biochemical and Biophysical Research Communications·Lorena CitterioCristina Barlassina
May 1, 2007·Pharmacogenomics·Paolo ManuntaMara Ferrandi
Dec 12, 2012·PloS One·Roger López-BellidoRaquel E Rodríguez
Feb 18, 2005·Journal of Hypertension·Chiara LanzaniPaolo Manunta
May 24, 2003·Annals of the New York Academy of Sciences·Giuseppe Bianchi, Grazia Tripodi

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