Utilization of commercial laboratory results in management of hyperandrogenism in women.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
E SteinbergerG G Reimondo

Abstract

To compare results from testosterone radioimmunoassay kits commonly used by commercial laboratories as well as their reference ranges and to analyze the scientific literature for ranges of serum testosterone levels in normal women and those with hyperandrogenism. We reviewed quality assurance reports of various testosterone ligand challenges from four groups of laboratories and summarized testosterone data from 17 published reports about normal women and 14 studies of hyperandrogenic women. A significant variability was demonstrated between the radioimmunoassay kits at all concentrations (for example, a sample with a mean testosterone level of 96.1 ng/dL was reported by some laboratories as containing 71.8 ng/dL and by others as 123.4 ng/dL). All laboratories provide essentially the same "reference range" (approximately 10 to 90 ng/dL) but do not report how the range was established. The scientific literature clearly shows a significant separation in serum testosterone levels between normal (that is, not hyperandrogenic) and hyperandrogenic women. Most hyperandrogenic women had testosterone levels >50 ng/dL, whereas most normal control subjects had levels <40 ng/dL. Thus, most of these women with hyperandrogenism would have bee...Continue Reading

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Citations

Apr 27, 2013·Reviews in Endocrine & Metabolic Disorders·Flaminia FanelliUberto Pagotto
Dec 4, 2003·Steroids·Frank Z StanczykRichard J Paulson
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·N A Mazer
Oct 7, 2008·Steroids·Hubert W VesperGary L Myers
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Hubert W Vesper, Julianne Cook Botelho
Aug 28, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·N F GoodmanUNKNOWN American Association of Clinical Endocrinologists Hyperandrogenic Disorders Task Force
Mar 16, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·L J Rodriguez-Rigau
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·C AyalaS M Petak
Jun 15, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rhoda H CobinUNKNOWN AACE Menopause Guidelines Revision Task Force

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