PMID: 108991Jun 1, 1979

Utilization of D-methionine during total parenteral nutrition in postsurgical patients

The American Journal of Clinical Nutrition
K J PrintenL D Stegink

Abstract

Utilization of intravenously administered D-methionine was measured by morbidly obese subjects fed parenterally after elective gastric bypass surgery. Five patients were infused with a 25% glucose--4.25% amino acid solution containing DL-methionine, and four were treated with a 25% glucose--3.5% amino acid solution containing only L-methionine. Mean (+/- SD) total daily methionine excretion was 0.06 +/- 0.04 mmoles (of 28 +/- 4 mmoles infused) in patients treated with the L-methionine containing solution, and was 15.2 +/- 4.2 mmoles/day (of 45.2 +/- 5 mmoles DL-isomer infused) in patients treated with the DL-methionine containing solution. In these latter patients, 90 to 98% of the excreted methionine was the D-isomer. The data indicate 64 +/- 23% of infused D-methionine is excreted in the urine. Four patients excreted between 70 to 85% of infused D-methionine in the urine, but one patient excreted only 35 to 55%, suggesting better utilization. Plasma methionine levels were higher (9.9 +/- 1.9 mumoles/100 ml) in patients infused with solutions containing DL-methionine than those infused with the L-methionine solution (4.5 +/- 1.0 mumoles/100 ml). In the former case, 49% of plasma methionine was the D-isomer. The data indicate p...Continue Reading

Citations

Dec 1, 1996·Hearing Research·Kathleen C M CampbellL F Hughes
Nov 27, 1999·Hearing Research·Kathleen C M CampbellL F Hughes
Jan 17, 2007·Hearing Research·Kathleen C M CampbellLarry F Hughes
Jun 28, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kurtis D KorverKathleen C M Campbell
Dec 8, 1993·Molecular and Cellular Biochemistry·P W Scislowski, K Pickard
Nov 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·E S ChoL D Stegink
Apr 27, 2011·Amino Acids·Mendel Friedman, Carol E Levin
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Saleha B VuyyuriAlnawaz Rehemtulla

Related Concepts

Erythrocytes
Glucose, (beta-D)-Isomer
Pedameth
Obesity
Parenteral Nutrition
Parenteral Nutrition, Total
Postoperative Procedures
Molecular Stereochemistry
Stomach

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