PMID: 7091374Jul 1, 1982Paper

Utilization of endogenous lipid, glycogen, and protein by rabbit aorta

The American Journal of Physiology
R Odessey, K V Chace

Abstract

The utilization of endogenous stores by rabbit aorta in vitro was measured. In substrate-free medium glycogen disappearance may account for less than 20% of the tissue O2 consumption during incubations of less than 2-3 h. At longer times (or in the presence of glucose) glycogen catabolism is negligible. Calculations from the rate of proteolysis suggest that oxidation of endogenously generated amino acids accounts for less than 7-10% of the oxygen consumption. Furthermore, the presence of amino-oxyacetate, a transaminase inhibitor, did not alter the ATP-ADP ratio. By contrast, measurements of the disappearance of tissue triglyceride indicate that endogenous lipid could meet the fuel requirements of the aorta. Direct measurement of intracellular fatty acid oxidation was obtained by measuring acyl carnitine specific activity and 14CO2 production from [1-14C]palmitate. Fatty acid oxidation could account for at least 90% of the total O2 consumption, and 83% of the fatty acids consumed were derived from endogenous tissue stores. Octanoate was found to inhibit both exogenous and endogenous fatty acid oxidation. These findings may indicate that shorter-chain fatty acids may be preferentially utilized by the aorta.

Citations

Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T J Allen, C D Hardin
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·R M LeachJ T Sylvester

Related Concepts

Aminooxyacetate
Descending Aorta
Energy Metabolism
Saturated Fat
Glycogen
Glycolysis
Ketone Bodies
Oxygen Consumption
Lipid Metabolism

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.