PMID: 43582Nov 1, 1979

Utilization of exogenous acetate during canine haemorrhagic shock

Scandinavian Journal of Clinical and Laboratory Investigation
M Kveim, R Nesbakken

Abstract

Plasma acetate and lactate, as well as acid-base-parameters were followed during acetate (dogs I-V) or lactate (dogs VI-X) loading during stable hypotension (mean arterial blood pressure 30 mmHg). Acetate or lactate were infused at a constant rate of 4 mmol/kg/h as 0.5 mol/l solutions (50% as the sodium salt, 50% as the free acid) without simultaneous treatment of the volume deficit. The acetate metabolizing capacity was well preserved even in profound haemorrhagic shock. The actual loads were rapidly removed, while the equivalent lactate loads caused progressive accumulation of the lactate ion. Acetate loading did not aggravate the lactic acidosis, and the acid-base-parameters showed a more favourable development during acetate loading than during lactate loading. Acetate may thus be given during haemorrhagic shock without the same risk of accumulation that is carried by the equivalent amounts of lactate.

References

Aug 10, 2002·Anesthesiology·Dan Drobin, Robert G Hahn
Nov 25, 2004·Anesthesia and Analgesia·Joel OlssonRobert G Hahn
Jul 10, 2014·Kidney International·Can Ince, A B Johan Groeneveld
Mar 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Sumeet ReddyPaul Young
Oct 16, 2013·The Journal of Surgical Research·Ricarda RohrigHerbert de Groot
Jul 13, 2016·BioMed Research International·Indra N WaackHerbert de Groot
Nov 30, 2016·World Journal of Critical Care Medicine·Laurence WeinbergRinaldo Bellomo
Aug 12, 1998·European Journal of Anaesthesiology·R G Hahn

Citations

Nov 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·M KveimJ E Bredesen
Feb 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Kveim, J E Bredesen
Mar 1, 1975·Acta Physiologica Scandinavica·N KarlssonK H Kiessling
Aug 9, 1969·Lancet·R A CashR A Phillips
Dec 1, 1973·The Journal of Clinical Investigation·F LUNDQUISTJ Trap-Jensen
Jul 31, 1965·Annals of the New York Academy of Sciences·D R Drury
Nov 14, 1970·British Medical Journal·H E EliahouE Reisin
Jul 1, 1969·Archives of Surgery·V JohnsonB Eiseman
Feb 10, 1962·Nature·F LUNDQUIST
May 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·G H MUDGEA GILMAN

Related Concepts

Neurologic Manifestations
Lactate
Shock
Lactic Acid Measurement
Lactates
Biologic Preservation
Body Surface Area Formula for Dogs
Sodium salts
Hypotension, Controlled
Anion Gap

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