Utilization of Fourier transform-Raman spectroscopy for the study of pharmaceutical crystal forms

Journal of Pharmaceutical and Biomedical Analysis
W P Findlay, David E Bugay

Abstract

It is well understood that the solid state physical characterization of a drug substance is necessary for successful development and approval of a pharmaceutical product AAPS [1]. Physical analytical techniques used include: XRD, IR, DSC, TG, and NMR. Recently, Fourier transform (FT) Raman spectroscopy has become a more common technique. Complimentary to IR, FT-Raman can be used to differentiate between different crystal forms of a drug substance. FT-Raman exhibits several advantages over IR and the other physical analytical techniques. Very little sample is required with no preparation (dilution), analysis time is quick, and since water is a weak scatter (Raman spectrum of water contains three low intensity peaks), crystallization studies of drug substances from aqueous solutions can be performed. Additionally, through the use of a variable-temperature accessory, phase diagrams can be determined for crystal systems, leading to further characterization of those systems. This paper introduces the use of FT-Raman spectroscopy for pharmaceutical development activities. Specific examples will be shown for investigations of crystal forms (qualitative and quantitative) and crystallization studies.

References

Oct 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·W Plugge, C van der Vlies
Apr 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·F González, R Pous

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Citations

Jun 11, 2005·Pharmaceutical Research·Harry G BrittainAllen H Salerno
Apr 1, 2006·Pharmaceutical Research·Takashi KojimaYoshihisa Matsuda
Feb 14, 2004·Advanced Drug Delivery Reviews·Barbara Rodríguez-SpongNaír Rodríguez-Hornedo
May 26, 2005·International Journal of Pharmaceutics·S C PérezS L Cuffini
Apr 28, 2001·Advanced Drug Delivery Reviews·G A StephensonS M Reutzel-Edens
Apr 28, 2001·Advanced Drug Delivery Reviews·D E Bugay
May 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·S Agatonovic-KustrinI G Tucker
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·N Al-ZoubiS Malamataris
Jul 13, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Geert J VergoteFrancis Verpoort
Nov 18, 2014·Expert Opinion on Drug Discovery·Urvi Gala, Harsh Chauhan
Apr 29, 2005·Journal of Pharmaceutical Sciences·Shawn M MehrensXianggui Qu
Jul 3, 2010·Journal of Pharmaceutical Sciences·Zoran LavričStane Srčič
Mar 13, 2016·Journal of Pharmaceutical and Biomedical Analysis·A HertrampfT Herdling
Dec 7, 2007·Drug Discovery Today·Lokesh KumarArvind K Bansal
Aug 25, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrea HeinzClare J Strachan
Nov 8, 2003·The Journal of Pharmacy and Pharmacology·V Brett CooperCatherine R Petts
Apr 15, 2004·International Journal of Pharmaceutics·Adrian C WilliamsSteven W Booth
Jun 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·A HertrampfT Herdling
Nov 23, 2010·Journal of Pharmaceutical and Biomedical Analysis·Predrag NovakGordana Verbanec
Jul 2, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andrea HeinzClare J Strachan
Jun 28, 2006·Journal of Pharmaceutical Sciences·Birju ShahArvind K Bansal
Dec 12, 2013·The Journal of Pharmacy and Pharmacology·Yongcheng LiChuangbin Wu
Mar 15, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·C Yohannan PanickerDaizy Philip
Feb 1, 2009·Drug Testing and Analysis·H R H AliI J Scowen
Feb 3, 2007·The Journal of Pharmacy and Pharmacology·Jukka Rantanen
Oct 3, 2002·The Journal of Pharmacy and Pharmacology·Hong Yang, Joseph Irudayaraj
May 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Pentti NiemeläKristiina Järvinen

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