Utilization of Genetic Counseling after Direct-to-Consumer Genetic Testing: Findings from the Impact of Personal Genomics (PGen) Study

Journal of Genetic Counseling
Diane R KoellerPGen Study Group

Abstract

Direct-to-consumer personal genomic testing (DTC-PGT) results lead some individuals to seek genetic counseling (GC), but little is known about these consumers and why they seek GC services. We analyzed survey data pre- and post-PGT from 1026 23andMe and Pathway Genomics customers. Participants were mostly white (91%), female (60%), and of high socioeconomic status (80% college educated, 43% household income of ≥$100,000). After receiving PGT results, 43 participants (4%) made or planned to schedule an appointment with a genetic counselor; 390 (38%) would have used in-person GC had it been available. Compared to non-seekers, GC seekers were younger (mean age of 38 vs 46 years), more frequently had children <18 (26% vs 16%), and were more likely to report previous GC (37% vs 7%) and genetic testing (30% vs 15%). In logistic regression analysis, seeking GC was associated with previous GC use (OR = 6.5, CI = 3.1-13.8), feeling motivated to pursue DTC-PGT for health reasons (OR = 4.3, CI = 1.8-10.1), fair or poor self-reported health (OR = 3.1, CI = 1.1-8.3), and self-reported uncertainty about the results (OR = 1.8, CI = 1.1-2.7). These findings can help GC providers anticipate who might seek GC services and plan for clinical discu...Continue Reading

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Citations

Mar 13, 2019·Journal of Genetic Counseling·Johanna L SchmidtSharon Reid Altmeyer
Jun 7, 2019·Molecular Diagnosis & Therapy·Susanne B Haga
Jul 11, 2020·Journal of Genetic Counseling·Tessa MarzullaWendy R Uhlmann
Jul 4, 2020·Nursing·Elena FlowersJanet K Shim
Mar 23, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephany Tandy-ConnorBrigette Tippin Davis
Feb 23, 2018·Molecular Genetics & Genomic Medicine·Catharine WangJames J Cummings
Mar 3, 2018·Frontiers in Public Health·Jane Tiller, Paul Lacaze
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Nov 7, 2019·Journal of Personalized Medicine·M Cabell JonasElizabeth A McGlynn
Aug 1, 2020·Annual Review of Medicine·Mary A MajumderAmy L McGuire
Sep 3, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Anna DochertyHilary Coon
Sep 5, 2021·Journal of Behavioral Medicine·Arielle S GillmanRebecca A Ferrer

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