PMID: 8941525Nov 1, 1996Paper

Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise

Journal of Applied Physiology
S R ColbergD Kelley

Abstract

To test the hypothesis that substrate utilization during mild-intensity exercise differs in non-insulin-dependent diabetes mellitus (NIDDM) compared with nondiabetic subjects, seven lean healthy subjects (L), seven obese healthy subjects (O), and seven individuals with NIDDM were studied during 40 min of mild-intensity cycling (40% of peak O2 uptake). Systemic utilization of plasma glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During exercise, when CHO oxidation was greater than Glc Rd, the net oxidation of glycogen was calculated as the difference: CHO oxidation - Glc Rd. During mild-intensity cycling, the respiratory exchange ratio was similar across groups (0.87 +/- 0.02, 0.85 +/- 0.02, and 0.86 +/- 0.01 in L, O, and NIDDM subjects, respectively), and CHO oxidation accounted for one-half of total energy expenditure during exercise. Glc Rd increased during exercise and was greatest in subjects with NIDDM (3.0 +/- 0.2, 2.9 +/- 0.2, and 4.5 +/- 0.4 ml.kg-1.min-1 in L, O, and NIDDM subjects, respectively, P < 0.05), yet Glc Rd was less than CHO oxidation during exercise, indicating net oxidation of glycogen. Glycogen oxid...Continue Reading

References

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Citations

Jun 28, 2001·Medicine and Science in Sports and Exercise·P D ThompsonL Pescatello
Jun 28, 2001·Medicine and Science in Sports and Exercise·D E Kelley, B H Goodpaster
Jul 10, 2002·Obesity Research·Bret H GoodpasterDavid E Kelley
Jun 22, 2017·Journal of Diabetes Research·Christopher J GaffneyKostas Tsintzas
Jun 6, 2018·American Journal of Physiology. Endocrinology and Metabolism·Rodrigo Fernández-VerdejoJosé E Galgani
Feb 2, 1999·Medicine and Science in Sports and Exercise·J KangS G Dasilva
Jul 28, 2001·Medicine and Science in Sports and Exercise·P PoirierA Nadeau
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Henrik GalboLuc J C van Loon
Nov 19, 2010·Medicine and Science in Sports and Exercise·Sheri R ColbergUNKNOWN American Diabetes Association
Jan 10, 2017·Frontiers in Nutrition·Nathan CaronGeorges Dalleau
May 11, 2004·Journal of Applied Physiology·Barry BraunFrancesca Beaudoin
Sep 1, 2005·Obesity Research·Marco MensinkWim H Saris
Dec 5, 2012·Annals of Nutrition & Metabolism·Jonida HaxhiMassimo Sacchetti
Nov 28, 2018·BMC Sports Science, Medicine and Rehabilitation·Fred J DiMenna, Avigdor D Arad
Jun 13, 2020·Diabetologia·Mladen Savikj, Juleen R Zierath
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael G ClarkStephen Rattigan
Nov 25, 2000·Journal of Applied Physiology·J F Horowitz, S Klein
Mar 15, 2006·Medicine and Science in Sports and Exercise·Adam L MacDonaldPeter W Watt
Mar 4, 2020·International Journal of Molecular Sciences·Avigdor D AradFred J DiMenna
Jan 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Donato A RivasJohn A Hawley
Jan 11, 2011·Diabetes/metabolism Research and Reviews·Richard MackenziePeter Watt
Mar 20, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yet Hoi HongGlenn K McConell
Jun 11, 2020·Medicine and Science in Sports and Exercise·Lisa ChuBrian W Timmons
May 4, 2017·Cell Metabolism·Bret H Goodpaster, Lauren M Sparks

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