Utilization of GnRH agonists for poor responders in an IVF programme

Human Reproduction
J Belaisch-AllartR Frydman

Abstract

Thirty-four patients in whom conventional ovarian stimulation had previously failed twice due to low levels of oestradiol, received ovarian stimulation by pure FSH for 5 days, followed by a combination of FSH and HMG, after a preliminary period of pituitary de-sensitization with LHRH agonist. Oocytes were recovered from 33 patients and 28 embryos replaced, 10 became pregnant and eight pregnancies were ongoing and resulted in the birth of 13 healthy babies. This ongoing pregnancy rate of 23.5% per treatment cycle is identical to that reported for normally responding patients. The use of LHRH agonists in so-called poor responders is of obvious interest.

Citations

Feb 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·Z Ben-RafaelS Mashiach
Jun 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G PadosS Mantalenakis
Jul 13, 1999·Human Reproduction·V Karande, N Gleicher
May 1, 1997·British Journal of Obstetrics and Gynaecology·S D KeayJ M Jenkins
Aug 16, 2000·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S ZafeiriouS Michalas
Oct 10, 2001·Human Fertility : Journal of the British Fertility Society·S F Marcus, W L Ledger
Feb 1, 1993·Journal of Assisted Reproduction and Genetics·F OlivennesR Frydman

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