Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

Regenerative Biomaterials
Teng-Teng CaiXian-Zheng Zhang

Abstract

A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

References

Feb 19, 2005·Seminars in Oncology·David S AlbertsAlberto A Gabizon
May 26, 2007·Angewandte Chemie·Peisheng XuYouqing Shen
Aug 14, 2010·Biomaterials·Sung Ho KimJames L Hedrick
Mar 25, 2011·Advanced Materials·José A BarretoLeone Spiccia
Jul 15, 2011·Journal of the American Chemical Society·Jing SuPhillip B Messersmith
Mar 1, 2012·Acta Biomaterialia·Bin YangRen-xi Zhuo
Sep 1, 2012·Journal of the American Chemical Society·Bala Kishan GorityalaXue-Wei Liu
Nov 9, 2012·Macromolecular Rapid Communications·Arthur BertrandJulien Bernard
Jan 29, 2013·Biomaterials·Daniele Rubert NogueiraM Pilar Vinardell
Mar 30, 2013·Biomaterials·Kai HanXian-Zheng Zhang
Feb 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huihui KuangYubin Huang

❮ Previous
Next ❯

Citations

Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Guilei MaDeling Kong
Jul 15, 2015·ACS Applied Materials & Interfaces·Hong ChengXian-Zheng Zhang
Feb 10, 2018·Regenerative Biomaterials·Boxuan MaYunbing Wang
May 26, 2018·Plastic and Reconstructive Surgery·Sanjay NaranJesse A Taylor
Mar 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pinghui ZhouBin Li
Oct 1, 2020·Biomaterials Science·Tongyi ShangBin Yang
May 13, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Hongchun Li, Yongsheng Niu

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
fluorescence spectroscopy
ELISA
size-exclusion chromatography
NMR
1
H

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.