PMID: 7539563Jun 1, 1995Paper

Utilization of high molecular weight cytokeratin on prostate needle biopsies in an independent laboratory

Urology
H KahaneJ I Epstein

Abstract

Immunoperoxidase staining of prostate tissues with antibodies to high molecular weight cytokeratin, which selectively labels basal cells, has recently been shown to be useful in the diagnosis of prostate cancer in academic centers. A growing sector in pathology is large independent laboratories, where little is known regarding practice patterns. The following study evaluated the use of high molecular weight cytokeratin in an independent laboratory specializing in prostate needle biopsies. In a 2-month period (July 1, 1994 to August 31, 1994), 4047 prostate needle biopsies were evaluated. Without the use of ancillary studies, 2710 (67%) were diagnosed as benign, 978 (24.1%) were diagnosed as cancer, and 23 (0.6%) were diagnosed as high-grade prostate intraepithelial neoplasia. The remaining 336 atypical cases (8.3%) were further evaluated with antibodies to higher molecular weight keratin. Of the 336 cases, 253 (6.2% of total) were resolved as diagnostic for cancer, 68 (1.7% of total) were diagnosed as benign, and 15 (0.4% of total) remained atypical. The cost of performing high molecular weight cytokeratin was approximately $5.00 per case, which was not passed on to the patient. The use of high molecular weight cytokeratin decr...Continue Reading

References

Dec 1, 1992·The American Journal of Surgical Pathology·J I Epstein, O A Armas
Apr 1, 1992·The American Journal of Surgical Pathology·D J GrignonA G Ayala
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkadaS Morii
Jul 1, 1991·The American Journal of Surgical Pathology·N SakamotoM Enjoji
May 1, 1989·The American Journal of Surgical Pathology·L Hedrick, J I Epstein
Oct 1, 1989·The American Journal of Surgical Pathology·B M Ronnett, J I Epstein

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Citations

Jul 7, 2005·Pathology Oncology Research : POR·Fernanda de Barros Correia CavalcantiLuís Balthazar Saldanha
Oct 3, 2007·Prostate Cancer and Prostatic Diseases·G Godoy, S S Taneja
May 16, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuichi TsujimotoKatsuyuki Aozasa
Mar 1, 1997·The American Journal of Surgical Pathology·S J Cina, J I Epstein
May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·David E Tacha, Rodney T Miller
Jun 13, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·M ShinK Aozasa
Jan 11, 2007·Journal of Clinical Pathology·P A Humphrey
May 8, 2001·American Journal of Clinical Pathology·P Thorson, P A Humphrey
Sep 21, 2007·Journal of Cellular Biochemistry·Chiara Grisanzio, Sabina Signoretti
Jan 4, 2012·Histopathology·David G Bostwick, Liang Cheng
Mar 4, 2006·Seminars in Diagnostic Pathology·Omar Hameed, Peter A Humphrey
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A M GownH Battifora
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Aug 23, 2017·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Jul 29, 2003·The American Journal of Surgical Pathology·Cristina Magi-GalluzziJonathan I Epstein

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