PMID: 3761523Sep 1, 1986Paper

Utilization of Intralipid in septic rats: effects of sepsis on the clearance of exogenous fat emulsion from various organs

JPEN. Journal of Parenteral and Enteral Nutrition
W J Chen

Abstract

The rats were used for the study of the effects of sepsis on the utilization of exogenous fat emulsion. The studies were carried out by measuring the rate and the pattern of clearance of intravenously-administered 14C-Intralipid from the plasma, liver, spleen, kidney, and muscle of control and septic rats. Plasma clearance of the exogenous fat measured for 14C at 30, 60, 90, 120, 360 min (n = 5) after intravenous injection revealed that the clearance was retarded by sepsis. In the liver, the initial 14C uptake was much greater in the septic rats than those in the control group (34.8 +/- 3.6% vs 14.4 +/- 1.6%, p less than 0.01). Six hr after injection, as high as 19.6 +/- 2.4% of the injected dose was detected in the liver of the septic rats, but the control rats had only 4.4 +/- 0.8%. In spleen, kidney, and muscle, however, both the 14C uptake and the rate of its clearance were greater for the control rats than those of the septic group. The increase in the amount of liver uptake of the exogenous fat by the septic rat and the retained large amount of the fat may account for the decreased plasma clearance and the decrease in its subsequent utilization by other organs and tissues. Significant increase in liver contents of total l...Continue Reading

References

Jun 1, 1976·Metabolism: Clinical and Experimental·R L KaufmannW R Beisel
Sep 1, 1979·The Journal of Trauma·Y A CarpentierJ M Kinney
Nov 1, 1979·Annals of Surgery·H FreundJ E Fischer
Jun 1, 1979·Archives of Surgery·K A WichtermanA E Baue
Aug 1, 1973·Acta Physiologica Scandinavica·F Bonde-PetersenH G Knuttgen
May 1, 1974·The Journal of Trauma·F E GumpJ M Kinney
Oct 18, 1980·Lancet·G W FischerA D Mease
Jan 1, 1983·The British Journal of Surgery·H B StonerE Gross
May 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·I GiovanniniG Castiglioni
Jan 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·W J Chen
Jan 1, 1980·Annals of Surgery·F B CerraR R McMenamy
Mar 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·G H ClowesC J Cha
Aug 1, 1980·The Journal of Surgical Research·K A WichtermanI H Chaudry
Sep 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·A P RobinJ M Kinney
Dec 1, 1964·Acta Physiologica Scandinavica·P BELFRAGET OLIVECRONA

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Citations

Jul 1, 1997·Critical Care Clinics·G J Schears, C S Deutschman
Feb 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J P Grant
Sep 1, 1996·The British Journal of Surgery·J S SamraK N Frayn

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