Utilization of intraoperative confocal laser endomicroscopy in brain tumor surgery

Journal of Neurosurgical Sciences
Evgenii BelykhPeter Nakaji

Abstract

Precise identification of tumor margins is of the utmost importance in neuro-oncology. Confocal microscopy is capable of rapid imaging of fresh tissues at cellular resolution and has been miniaturized into handheld probe-based systems suitable for use in the operating room. We aimed to perform a literature review to provide an update on the current status of confocal laser endomicroscopy (CLE) technology for brain tumor surgery. Aside from benchtop confocal microscopes used in ex vivo fashion, there are four CLE systems that have been investigated for potential application in the workflow of brain tumor surgery. Preclinical studies on animal tumor models and clinical studies on human brain tumors have assessed in vivo and ex vivo imaging approaches, suggesting that confocal microscopy holds promise for rapid identification of the characteristic (diagnostic) histological features of tumor and normal brain tissues. However, there are few studies assessing diagnostic accuracy sufficient to provide a definitive determination of the clinical and economical value of CLE in brain tumor surgery. Intraoperative real-time, high-resolution tissue imaging has significant clinical potential in the field of neuro-oncology. CLE is an emerging...Continue Reading

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Citations

Aug 6, 2018·International Journal of Computer Assisted Radiology and Surgery·Marc AubrevilleAndreas Maier
Oct 22, 2019·Frontiers in Surgery·Karl-Michael SchebeschChristian Doenitz
Aug 6, 2019·Frontiers in Oncology·Patra CharalampakiAxel Heimann
Oct 3, 2020·Journal of Clinical Medicine·Evgenii BelykhMark C Preul
Jun 3, 2021·Journal of Clinical Medicine·Francesco RestelliFrancesco Acerbi

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