Utilization of iron dextran in recurrent iron deficiency anaemia

British Journal of Haematology
L M KernoffE D du Toit

Abstract

Previously published studies have documented a reduction in the rate at which iron stores laid down by iron dextran therapy can be utilized for haemoglobin synthesis after the acute demands of haemorrhage and phlebotomy. In order to determine if a defect in the mobilization of these stores exists in the face of a chronic stimulus to red cell production, 93 patients who had previously received a total dose infusion of iron dextran were examined for a recurrence of iron deficiency anaemia, and in those in whom anaemia had recurred, iron stores were assessed by marrow aspiration. Twenty of the 93 patients were found to have recurrent iron deficiency anaemia, and marrow aspiration in all failed to demonstrate stainable iron stores. Although the rate at which iron dextran can be mobilized from storage sites is reduced, the present study demonstrates that ultimately these stores are fully utilizable.

References

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Citations

Oct 6, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Mehvar
Jan 1, 1984·International Journal of Aging & Human Development·D A Counts, D R Counts
Apr 1, 1987·Revista da Escola de Enfermagem da U S P·Elizabeth FujimoriHisako Shima
Jan 31, 2002·American Journal of Public Health·Nancy L SloanBeverly Winikoff
Jan 1, 1985·Critical Reviews in Oncology/hematology·A Jacobs

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