Utilization of myoglobin as a heme source by Haemophilus influenzae requires binding of myoglobin to haptoglobin

FEMS Microbiology Letters
Daniel J MortonTerrence L Stull

Abstract

Haemophilus influenzae has an absolute growth requirement for heme. One potential in vivo source of heme is the protein myoglobin which is found at low levels in human serum. No tested H. influenzae strain was able to use myoglobin as a heme source. However, all strains were able to utilize the heme from myoglobin when myoglobin was complexed with haptoglobin. Utilization of the haptoglobin-myoglobin complex was shown to be mediated by the previously described hemoglobin/hemoglobin-haptoglobin-binding proteins of H. influenzae.

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Citations

Jul 21, 2006·Journal of Bacteriology·Paul W WhitbyTerrence L Stull
Apr 20, 2010·BMC Microbiology·Daniel J MortonTerrence L Stull
Nov 1, 2007·Academic Medicine : Journal of the Association of American Medical Colleges·Jordan J Cohen
Jan 16, 2010·Microbiology·Paul W WhitbyTerrence L Stull
May 2, 2012·Journal of Proteomics·Fausto ScoppettaElisabetta Chiaradia
Jul 10, 2013·Infection and Immunity·Nermi L ParrowMichael F Minnick
Jan 7, 2011·Medical Education·Eva M Doherty, Emmeline Nugent

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