Abstract
To describe utilization of 3% hypertonic saline (HTS) in hospitalized infants and to evaluate the association between HTS use and length of stay (LOS) in a real-world setting. This multicenter retrospective cohort study included infants≤12 months hospitalized with bronchiolitis between October 2008 and September 2011 using the Pediatric Health Information System. HTS use was categorized as trial, rescue, daily, or sporadic. Differences in LOS were compared after matching daily HTS recipients and nonrecipients on propensity score. There were 63,337 hospitalizations for bronchiolitis. HTS was used in 24 of 42 hospitals and 2.9% of all hospitalizations. HTS use increased from 0.4% of visits in 2008 to 9.2% of visits in 2011. There was substantial variation in HTS use across hospitals (range 0.1%-32.6%). When used, HTS was given daily during 60.6% of hospitalizations, sporadically in 10.4%, as a trial in 11.3%, and as a rescue in 17.7%. The propensity score-matched analysis of daily HTS recipients (n=953) vs nonrecipients (n=953) showed no difference in mean LOS (HTS 2.3 days vs nonrecipients 2.5 days; β-coefficient -0.04; 95% CI -0.15, 0.07; P=.5) or odds of staying longer than 1, 2, or 3 days. Daily HTS recipients had a 33% decre...Continue Reading
References
Oct 27, 1999·JAMA : the Journal of the American Medical Association·D K ShayL J Anderson
Feb 11, 2003·Chest·Avigdor MandelbergIsrael E Priel
Sep 3, 2004·The Journal of Pediatrics·Caroline Breese Hall
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·Sherry WeitzenVincent Mor
Oct 7, 2004·Pediatrics·Aileen B SedmanDarrell A Campbell
Apr 5, 2005·Pediatrics·Dimitri A ChristakisDanielle M Zerr
Oct 4, 2006·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis
Nov 4, 2009·Archives of Pediatrics & Adolescent Medicine·Simran GrewalTerry P Klassen
Dec 3, 2009·Pediatric Pulmonology·Ayse Berna AnilNejat Aksu
Jan 27, 2010·Pediatrics·Joseph J Zorc, Caroline Breese Hall
Jul 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z LuoX Yang
Jul 22, 2010·The Journal of Pediatrics·Khalid Al-AnsariKhalid Ibrahim
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Daniel WestreichTil Stürmer
Oct 8, 2011·Pulmonary Pharmacology & Therapeutics·Ilke Ozahı IpekAbdulkadir Bozaykut
Oct 29, 2014·Pediatrics·Shawn L RalstonSinsi Hernandez-Cancio
Citations
Mar 22, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jeffrey Baron, Gladys El-Chaar
Feb 24, 2016·Expert Review of Respiratory Medicine·Silvia VandiniMarcello Lanari
Sep 4, 2015·Pediatric Pulmonology·Pedro FloresAna S Neto
May 14, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Christopher L Carroll The Northeast Pediatric Critical Care Research Consortium
Jun 18, 2017·Hospital Pediatrics·Steven L SheinBenjamin Gaston
Sep 7, 2018·Clinical Pediatrics·Shadwa HassanPushpom James
Jul 7, 2017·Hospital Pediatrics·Mythili SrinivasanAyelet Rosen
Feb 6, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Steven L SheinAdrienne G Randolph