PMID: 6983565Dec 1, 1982Paper

Utilization of retinoids in the bullfrog retina

The Journal of General Physiology
J I PerlmanD R Pepperberg

Abstract

The capacity to generate 11-cis retinal from retinoids arising naturally in the eye was examined in the retina of the bullfrog, Rana catesbeiana. Retinoids, co-suspended with phosphatidylcholine, were applied topically to the photoreceptor surface of the isolated retina after substantial bleaching of the native visual pigment. The increase in photoreceptor sensitivity associated with the formation of rhodopsin, used as an assay for the appearance of 11-cis retinal in the receptors, was analyzed by extracellular measurement of the photoreceptor potential; in separate experiments using the isolated retina or receptor outer segment preparations, the formation of rhodopsin was measured spectrophotometrically. Treatments with the 11-cis isomers of retinal and retinol induced significant increases in both the rhodopsin content and photic sensitivity of previously bleached receptors. The all-trans isomers of retinyl palmitate, retinol, and retinal, as well as the 11-cis isomer of retinyl palmitate, were inactive by both the electrophysiological and spectrophotometric criteria for the generation of rhodopsin. Treatment with any one of the "inactive" retinoids did not abolish the capacity of subsequently applied 11-cis retinal or 11-cis...Continue Reading

Citations

Apr 8, 1996·The Journal of Comparative Neurology·R B HesslerF Gonzalez-Fernandez
Nov 1, 1990·Documenta Ophthalmologica. Advances in Ophthalmology·J C HuangC M Kemp
Jan 1, 1984·Vision Research·D R Pepperberg, J W Clack
Jan 1, 1984·Vision Research·G W GroenendijkF J Daemen
Mar 1, 1994·Visual Neuroscience·J JinM C Cornwall
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G J JonesG J Chader
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D W CorsonK Nakanishi
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T I OkajimaG J Chader
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D W CorsonK Nakanishi
Aug 5, 2000·The Journal of General Physiology·D W CorsonR K Crouch
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·T LiE L Berson
Jul 10, 2007·Experimental Eye Research·Albert MunizAndrew T C Tsin
Nov 30, 2010·Progress in Retinal and Eye Research·Jin-Shan Wang, Vladimir J Kefalov
Aug 16, 1996·The Journal of Biological Chemistry·B M BinderV Y Arshavsky

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