Utilization of the perfused stomach in anaesthetized rats to study the inhibitory effect of somatostatin in gastric acid secretion

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M J RobeinS Bonfils


The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine. Evidence is produced that somatostatin competitively inhibits gastrin-stimulated acid secretion whereas it inhibits carbamylcholine-stimulated acid secretion by a mechanism which is non-competitive in nature and it has no action on histamine-stimulated secretion. The model of the persued stomach in the anaesthetized rat seems suitable to study the inhibition caused by drug on stimulated acid secretion.


Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·F PaganiA Giachetti
Oct 1, 1988·Alimentary Pharmacology & Therapeutics·J R HeylingsM Feldman


Jan 1, 1977·Scandinavian Journal of Gastroenterology·S J KonturekA V Schally
Sep 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·S J KonturekA V Schally
Feb 1, 1977·Digestion·H HummeltF Waldeck
Jan 1, 1977·Scandinavian Journal of Gastroenterology·J PhillipL Demling
Oct 1, 1976·Pharmacological Research Communications·W Lippmann, L E Borella
Jan 1, 1974·Annual Review of Biochemistry·P Cuatrecasas
Dec 1, 1969·Acta Physiologica Scandinavica·L S Semb
Mar 1, 1958·British Journal of Pharmacology and Chemotherapy·M N GHOSH, H O SCHILD
Aug 1, 1964·Gut·S K LAI
Jun 1, 1962·The Journal of Physiology·V M ROSENOER, H O SCHILD

Related Concepts

Histamine Measurement
Gastric Juice
Process of Secretion
Drug Interactions
Metabolic Inhibition

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