Utilizing a low-carbohydrate/high-protein diet to improve metabolic health in individuals with spinal cord injury (DISH): study protocol for a randomized controlled trial

Trials
Ceren Yarar-FisherCasey Morrow

Abstract

Metabolic disorders (e.g., impaired glucose tolerance, insulin resistance, and type 2 diabetes) are more prevalent in people with spinal cord injury (SCI) than able-bodied individuals. Dietary modification is a more cost-effective treatment option than pharmacological therapies for reducing the risk of metabolic dysfunction. Lowering carbohydrate, increasing protein, and maintaining a proper dietary fat intake are expected to induce favorable adaptations in glucose control, body fat distribution, and the composition of the gut microbiome. However, dietary modification has not been rigorously investigated in people with SCI. The purpose of this study is to determine if an 8-week low-carbohydrate/high-protein (LC/HP) dietary intervention will show improvements in clinically important metrics of metabolic function, body composition, the composition of gut bacteria, and quality of life. We intend to recruit 100 participants with chronic traumatic SCI (3 years postinjury, C5-L2, American Spinal Injury Association impairment scale A-D, and aged 18-65 years) and insulin resistance, impaired glucose tolerance or untreated type 2 diabetes and randomly assign them to an 8-week LC/HP dietary intervention group or a control group. The dail...Continue Reading

Associated Clinical Trials

References

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Citations

Jan 12, 2021·Neurobiology of Pain·Courtney A BannermanNader Ghasemlou
Dec 22, 2019·Experimental Neurology·Matthew T Goodus, Dana M McTigue
Apr 4, 2021·Journal of Clinical Medicine·Jorge OjedaPía M Vidal
Apr 27, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Samantha Celeste Garcia-HernandezM Elba Gonzalez-Mejia
May 1, 2021·Frontiers in Nutrition·Joelle Leonie Flueck, Jill A Parnell

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