Utilizing drug-target-event relationships to unveil safety patterns in pharmacovigilance.

Expert Opinion on Drug Safety
Alexander Sebastian HauserMaurizio Sessa

Abstract

Signal detection is the most pivotal activity of signal management to guarantee that drugs maintain a positive risk-benefit ratio during their lifetime on the market. Signal detection is based on the systematic evaluation of available data sources, which have recently been extended in order to improve timely and comprehensive signal detection of drug safety problems. In recent years, attempts have been made to incorporate pharmacological data for the prediction of safety signals. Previous studies have shown that data on the pharmacological targets of drugs are predictive of post-marketing adverse events. However, current approaches limit such predictions to adverse events expected from the interaction of a drug with the main pharmacological target and do not take off-target interactions into consideration. The authors propose the application of predictive modeling techniques utilizing pharmacological data from public databases for predicting drug-target-event relationships deriving from main- and off-target binding and from which potential safety signals can be deduced. Additionally, they provide an operative procedure for the identification of clinically relevant subgroups for predicted safety signals.

References

Jun 1, 1977·British Journal of Clinical Pharmacology·M D Rawlins
May 31, 2002·Acta Crystallographica. Section D, Biological Crystallography·Helen M BermanChristine Zardecki
Nov 25, 2003·BMJ : British Medical Journal·J K Aronson, R E Ferner
Dec 21, 2004·Nucleic Acids Research·Ada HamoshVictor A McKusick
Dec 24, 2005·Nature Chemical Biology·Anton F FliriRobert A Volkmann
Jul 3, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Toine C G Egberts
Jul 3, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sidney N Kahn
Jul 16, 2008·Science·Monica CampillosPeer Bork
Jan 1, 2008·Current Drug Abuse Reviews·Thomas M Heffernan
Nov 3, 2009·Nature·Michael J KeiserBryan L Roth
Dec 17, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robin E Ferner, Jeffrey K Aronson
Jan 1, 2012·CPT: Pharmacometrics & Systems Pharmacology·D R Mould, R N Upton
Apr 22, 2014·Expert Review of Clinical Pharmacology·Cara Tannenbaum, Nancy L Sheehan
Sep 25, 2014·CPT: Pharmacometrics & Systems Pharmacology·S VilarG Hripcsak
Sep 25, 2015·Nucleic Acids Research·Sunghwan KimStephen H Bryant
Mar 10, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Antoni F Z WisniewskiG Niklas Norén
Dec 3, 2016·Nucleic Acids Research·Anna GaultonAndrew R Leach
Feb 22, 2017·Journal of Pharmacological and Toxicological Methods·James J LynchEric A G Blomme
Apr 17, 2017·Drug Discovery Today·Doris A SchuetzGerhard F Ecker
Apr 30, 2017·BMC Pharmacology & Toxicology·Matthieu ChartierRafael J Najmanovich
Oct 28, 2017·Nature Reviews. Drug Discovery·Alexander S HauserDavid E Gloriam
Nov 11, 2017·Nucleic Acids Research·David S WishartMichael Wilson
Dec 2, 2017·CPT: Pharmacometrics & Systems Pharmacology·Pengyue ZhangLang Li
Dec 19, 2017·Cell·Alexander S HauserM Madan Babu
Aug 22, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anna RadeckaJune Raine
Jan 1, 2017·Therapeutic Innovation & Regulatory Science·Marina LengsavathSusana Goncalves
Oct 26, 2018·CPT: Pharmacometrics & Systems Pharmacology·Peter SchotlandKeith Burkhart
Nov 22, 2018·Nucleic Acids Research·Denise Carvalho-SilvaIan Dunham
Mar 1, 2019·Journal of Chemical Information and Modeling·Dominique SydowAndrea Volkamer
Apr 11, 2019·Clinical Pharmacology and Therapeutics·Alison CavePeter Arlett
Aug 21, 2019·Therapeutic Advances in Drug Safety·Andrew BateRobert F Reynolds
Sep 13, 2019·Science Translational Medicine·Ann LinJason M Sheltzer

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