Utilizing gastric cancer organoids to assess tumor biology and personalize medicine

World Journal of Gastrointestinal Oncology
Miranda LinJoseph Kim

Abstract

While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are limited treatment options and survival remains poor. Therefore, there is an urgent need for more effective therapies. Since novel therapies require extensive preclinical testing prior to human trials, it is important to identify methods to expedite this process. Traditional cancer models are restricted by the inability to accurately recapitulate the primary human tumor, exorbitant costs, and the requirement for extended periods of development time. An emerging in vitro model to study human disease is the patient-derived organoid, which is a three-dimensional system created from fresh surgical or biopsy tissues of a patient's gastric tumor. Organoids are cultured in plastic wells and suspended in a gelatinous matrix, providing a substrate for extension and growth in all dimensions. They are rapid-growing and highly representative of the molecular landscape, histology, and morphology of the various subtypes of GC. Orga...Continue Reading

References

Oct 1, 1976·In Vitro·W A Nelson-ReesA J Kniazeff
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L R Kelland
Sep 23, 2008·Clinical Therapeutics·Patrick J Medina, Susan Goodin
Feb 18, 2010·Proteomics·Chris S HughesGilles A Lajoie
Nov 28, 2012·International Journal of Cancer. Journal International Du Cancer·Masahiro Asaka
Feb 26, 2013·Journal of the National Cancer Institute·Jean-Pierre GilletMichael M Gottesman
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 4, 2014·Cancer Discovery·Manuel HidalgoAlberto Villanueva
Jun 20, 2015·Cell·Toshiro Sato, Hans Clevers
Oct 21, 2015·Scientific Reports·Annalisa FrattiniEmanuela Maserati
Aug 16, 2016·Developmental Biology·Sebastian R MerkerDaniel E Stange
Aug 23, 2016·Gastroenterology Clinics of North America·Juan M Marqués-LespierMarcia Cruz-Correa
Mar 24, 2017·Cancer Discovery·Chantal PauliMark A Rubin
Apr 10, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sina Bartfeld, Hans Clevers
Jul 22, 2017·Current Gastroenterology Reports·Maya BalakrishnanDavid Y Graham
Sep 9, 2017·Nature Medicine·Anthony Letai
Apr 29, 2018·Gut·Therese SeidlitzDaniel E Stange
Aug 28, 2018·Cell·Kristin A KnouseAngelika Amon
Dec 14, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Taro FunakoshiTsutomu Chiba
Dec 14, 2018·International Journal of Molecular Sciences·Pontus Aspenström

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Citations

Oct 3, 2020·Cancers·George AlzeebCatherine Le Jossic-Corcos
Jan 23, 2020·World Journal of Gastrointestinal Oncology·Tasuku Matsuoka, Masakazu Yashiro
Sep 27, 2020·Cancers·Zarema GilazievaValeriya Solovyeva
Nov 24, 2020·Cell Death and Differentiation·Therese SeidlitzDaniel E Stange
May 28, 2021·Cancer Cytopathology·Jinhan XieAndrew J Gifford
Jul 10, 2021·Frontiers in Bioengineering and Biotechnology·Gabriela S KronembergerLeandra S Baptista
Sep 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Min-Jiao PangZhen-Ning Wang

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Methods Mentioned

BETA
dissection
xenograft
biopsies
biopsy
Xenografts
GTPase
surgical resection

Clinical Trials Mentioned

NCT03429816

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