Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides.

Biochemical Society Transactions
Sunnia RajputFrances Separovic


Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ peptide aggregates. The amyloid plaques and soluble oligomeric species of Aβ are believed to be the major cause of synaptic dysfunction in AD brain and their cytotoxic mechanisms have been proposed to involve interactions with cell membranes. In this review, we discuss our solid-state nuclear magnetic resonance (ssNMR) studies of Aβ interactions with model membranes.


Jan 1, 1988·European Biophysics Journal : EBJ·B A CornellF Separovic
Feb 18, 1972·Science·S J Singer, G L Nicolson
Jul 27, 1983·Biochimica Et Biophysica Acta·B A CornellC Morris
Apr 30, 1998·Neurobiology of Aging·K Yanagisawa, Y Ihara
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Aug 20, 2003·The Journal of Biological Chemistry·Kevin J BarnhamRoberto Cappai
Aug 21, 2003·Progress in Neurobiology·Paul R TurnerWickliffe C Abraham
Sep 19, 2003·European Biophysics Journal : EBJ·M S BallaF Separovic
Dec 9, 2003·IUBMB Life·Alison Drechsler, Frances Separovic
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin J BarnhamAshley I Bush
Jan 13, 2006·Journal of Molecular Biology·Tong-Lay LauFrances Separovic
Apr 6, 2006·The Journal of Biological Chemistry·David P SmithKevin J Barnham
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Christian Haass, Dennis J Selkoe
Mar 27, 2007·Journal of Molecular Biology·Maurits R R de PlanqueAnthony Watts
May 16, 2007·Journal of Structural Biology·Philipp Selenko, Gerhard Wagner
Nov 3, 2007·Current Opinion in Chemical Biology·Yee-Hung M Chan, Steven G Boxer
Dec 14, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Olga Simakova, Nelson J Arispe
Jan 26, 2008·European Biophysics Journal : EBJ·John D GehmanFrances Separovic
Mar 28, 2009·Neurobiology of Aging·Giuseppe D CiccotostoRoberto Cappai
Apr 28, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marc-Antoine SaniGerhard Gröbner
Mar 6, 2010·Current Protein & Peptide Science·L MillucciA Santucci
Feb 16, 2011·FEBS Letters·Marc-Antoine SaniFrances Separovic
Mar 5, 2011·Methods in Enzymology·Thomas B ActonGaetano T Montelione
Apr 20, 2013·Accounts of Chemical Research·Qing Zhe NiRobert G Griffin
May 20, 2014·American Journal of Alzheimer's Disease and Other Dementias·Lyudmila A TikhonovaGjumrakch Aliev
Jul 30, 2014·Angewandte Chemie·Robert HänselVolker Dötsch
Dec 1, 2012·Biophysics Reviews·Marc-Antoine SaniJohn D Gehman

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