UTP- and ATP-triggered transmitter release from rat sympathetic neurones via separate receptors

British Journal of Pharmacology
S BoehmP Illes

Abstract

In rat cultured sympathetic neurones, UDP, UTP and ATP at micromolar concentrations triggered Ca(2+)-dependent and tetrodotoxin-sensitive [3H]-noradrenaline release. The overflow evoked by UTP or ATP was similar at 100 mumol l-1, the concentration used in all subsequent experiments. Pre-exposure of the neurones to 100 mumol l-1 UTP significantly reduced ensuing secretory effects of UTP but not of ATP. Conversely, pre-exposure to ATP diminished the overflow due to ATP but not that due to UTP. In the presence of 10 mumol l-1 pyridoxal-5'-phosphate or 30 mumol l-1 suramin, the secretory response to ATP was reduced, but the effect of UTP was unaltered. Zn2+ (10 mumol l-1) reduced the overflow triggered by UTP, but increased the overflow due to ATP. These results indicate the presence of separate receptors for pyrimidine nucleotides and for purine nucleotides which both trigger transmitter release.

References

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Jul 1, 1993·Pflügers Archiv : European journal of physiology·R ClouesD A Brown
Nov 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·S Boehm
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Citations

May 13, 2006·Pflügers Archiv : European journal of physiology·Simon Hussl, Stefan Boehm
Apr 12, 2008·Purinergic Signalling·Stefan G Lechner, Stefan Boehm
Nov 21, 1996·European Journal of Pharmacology·R FröhlichP Illes
Mar 1, 1997·Trends in Pharmacological Sciences·D Communi, J M Boeynaems
Jun 4, 1999·Trends in Pharmacological Sciences·G P Connolly, J A Duley
Feb 1, 1997·Progress in Neurobiology·S Boehm, S Huck
Jul 1, 1997·British Journal of Pharmacology·W NörenbergP Illes
Dec 1, 1996·Journal of Autonomic Pharmacology·P IllesW Nörenberg
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Apr 30, 2009·Annual Review of Nutrition·Richard J WurtmanIsmail H Ulus
Jun 14, 2006·Brain Research Reviews·Mehmet Cansev
Sep 25, 2002·Physiological Reviews·R Alan North
Aug 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Michael HorckmansDidier Communi
Nov 30, 1999·Molecular Cell Biology Research Communications : MCBRC·K SakJ Järv

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