UTP induces vascular responses in the isolated and perfused canine epicardial coronary artery via UTP-preferring P2Y receptors

British Journal of Pharmacology
T MatsumotoS Chiba

Abstract

1. Vasoconstrictor responses of the isolated and perfused canine epicardial coronary artery to uridine 5'-triphosphate (UTP) were analysed pharmacologically. 2. At basal perfusion pressure, UTP induced vasoconstriction in a dose-related manner and the vasoconstriction was sometimes followed by a slight vasodilatation at large doses (more than 10 nmol). The rank order of potency for vasoconstriction was UTP = UDP > ATP > TTP > or = ITP > UMP. At raised perfusion pressure by 20 mM KCl, the vasoconstriction was not changed and a small vasodilatation was induced at large doses. The rank order of potency for vasodilatation was induced at large doses. The rank order of potency for vasodilatation was ATP > ITP > or = UDP > UTP > or = TTP. The maximal vasodilator response to UTP was much less than that to ATP. UMP did not induce vasodilatation. 3. The P2X receptor agonist and desensitizing agent alpha, beta-methylene ATP (1 microM) and the P2 receptor antagonist suramin (100 microM) inhibited the vasoconstrictor responses to ATP but not those to UTP and UDP. The P2 receptor antagonist reactive blue 2 (30 microM) did not inhibit the vascular responses to UTP. 4. UTP (200 microM) desensitized the vasoconstrictor responses to UTP, but not...Continue Reading

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Citations

May 14, 1999·European Journal of Pharmacology·A RubinoG Burnstock
Dec 21, 2014·Purinergic Signalling·Geoffrey Burnstock, Amir Pelleg
Mar 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J L BouchieE P Feener
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
May 5, 1999·Journal of Cardiovascular Pharmacology·L SeilerG Fleckenstein-Grün
Sep 15, 2007·The Journal of Pharmacology and Experimental Therapeutics·Shirley WeeJohn P Headrick
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D G Welsh, J E Brayden
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hideki NinomiyaHiroji Imamura
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T HoriuchiR G Dacey

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