UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production

Proceedings of the National Academy of Sciences of the United States of America
Simon R WoodGraham S Timmins

Abstract

Controversy continues both as to which wavelengths of sunlight cause melanoma and the mechanisms by which these different wavelengths act. Direct absorption of UVB by DNA is central in albino animal models, but melanin-pigmented models have shown major contributions by wavelengths longer than UVB that are thought to be mediated by photosensitized oxidant production. The only model for which the action spectrum of melanoma causation is known is a genetically melanoma-susceptible specific cross of Xiphophorus fish. We used electron paramagnetic resonance to quantitatively detect the UV induction of reactive melanin radicals in situ in the melanin-containing cells in the skin of this model and derived the action spectrum for melanin-photosensitized oxidant production (Phi(ox)). This action spectrum was identical to that for melanoma induction (Phi(mel)). These results confirm the hypothesis that melanin-photosensitized radical production is the major causative step of melanoma in this model and demonstrate that the wavelengths and mechanisms of melanoma causation in different models are dependent on the presence of melanin. This approach should be applicable to humans, thus providing an accurate surrogate for Phi(mel) for preventi...Continue Reading

References

Sep 29, 1978·Biochemical and Biophysical Research Communications·C C FelixR C Sealy
Aug 15, 1985·International Journal of Cancer. Journal International Du Cancer·M SchartlA Barnekow
Jul 1, 1989·Photochemistry and Photobiology·R D LeyT D Stuart
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowE Grist
Oct 1, 1989·The British Journal of Ophthalmology·A G CasswellJ L Hungerford
Feb 1, 1987·Photochemistry and Photobiology·W KorytowskiB Kalyanaraman
Apr 15, 1985·Cancer·J LuandeN Mohammed
Aug 1, 1984·Archives of Biochemistry and Biophysics·T Sarna, R C Sealy
Oct 1, 1993·Molecular & General Genetics : MGG·C M McEnteeA P Hudson
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B SetlowA D Woodhead
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K J LiuH M Swartz
May 1, 1993·Journal of the American Academy of Dermatology·H IhnY Ishibashi
Dec 23, 1995·Lancet·B L DiffeyJ L Rees
Dec 23, 1995·Lancet·J C de JongA D Osterhaus
Sep 1, 1995·Photochemistry and Photobiology·B CollinsW A Bryden
Aug 1, 1997·Journal of Photochemistry and Photobiology. B, Biology·H S BlackR M Tyrrell
Oct 9, 1998·The Journal of Investigative Dermatology·E WenczlA A Schothorst
Jan 16, 1999·Clinical Oncology : a Journal of the Royal College of Radiologists·M MalaguarneraG Pistone
Jun 17, 2000·Photochemistry and Photobiology·E S RobinsonR B Setlow
Sep 26, 2000·Journal of Cutaneous Medicine and Surgery·C J StreutkerL From
Apr 20, 2001·Journal of the American Academy of Dermatology·S Q WangR S Bart
Sep 28, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·N OzdemirS T Yavuzer
Apr 9, 2002·Pigment Cell Research·Simon AlalufAlan Heath
Jun 5, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Ronald D Ley
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Laurent FauchierDominique Babuty
Jul 24, 2003·Annals of Epidemiology·Cedric F GarlandEdward D Gorham
Aug 23, 2003·Journal of Magnetic Resonance·Ildar SalikhovHarold M Swartz
Dec 17, 2003·Archives of Dermatology·Caroline BevonaHensin Tsao
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bernhard Schaller, Rudolf Graf
Apr 20, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Shimin LiuKe Jian Liu
Sep 18, 2004·Cancer Research·Edward C De FaboGlenn Merlino
Oct 2, 2004·Photochemistry and Photobiology·Alexander SamokhvalovJohn D Simon
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seiji TakeuchiDouglas E Brash
Jan 26, 2005·Current Biology : CB·Judith JansGijsbertus T J van der Horst

❮ Previous
Next ❯

Citations

Jul 4, 2009·The Journal of Physical Chemistry. B·Alice WangJames R Norris
Sep 15, 2010·Oncogene·N C JenkinsD Grossman
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·David L MitchellIrma Gimenez-Conti
Jun 27, 2009·Journal of Toxicology and Environmental Health. Part a·Anna BrozynaBarbara W Chwirot
Nov 29, 2007·Zebrafish·Michael J CarvanD G Joakim Larsson
Sep 4, 2010·American Journal of Epidemiology·Marianne Berwick
Feb 6, 2008·Photochemistry and Photobiology·Nityanand Maddodi, Vijayasaradhi Setaluri
Apr 22, 2008·Photochemistry and Photobiology·Alice WangJames Norris
Dec 15, 2010·Photochemistry and Photobiology·André A FernandezDavid L Mitchell
Sep 30, 2008·Pigment Cell & Melanoma Research·Dorothy C Bennett
Dec 9, 2009·Pigment Cell & Melanoma Research·Sergio G Coelho, Vincent J Hearing
Mar 17, 2010·Pigment Cell & Melanoma Research·E Elizabeth PattonRodney S Nairn
Oct 29, 2010·Pigment Cell & Melanoma Research·Yoshinori MiyamuraVincent J Hearing
Aug 7, 2012·Pigment Cell & Melanoma Research·David Mitchell
Sep 24, 2011·Journal of Skin Cancer·Quentin Godechal, Bernard Gallez
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Agnessa Gadeliya GoodsonDouglas Grossman
Apr 5, 2013·BioMed Research International·Noah C Jenkins, Douglas Grossman
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hsiang-Tsui WangMoon-shong Tang
Mar 15, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Adam J ContrerasRonald B Walter
Feb 22, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kuan YangRonald B Walter
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stéphane MouretThierry Douki
Jul 2, 2009·Journal of Biomedical Optics·Reinhold EichhornKlaus Hoffmann
Mar 20, 2009·International Journal of Radiation Biology·Andrew J RidleySarah L Allinson
Apr 5, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·André A FernandezDavid L Mitchell
Jul 6, 2007·The Journal of Investigative Dermatology·Antonio Valencia, Irene E Kochevar
Mar 22, 2008·The Journal of Investigative Dermatology·Hironobu IkehataTetsuya Ono
Dec 28, 2007·Free Radical Biology & Medicine·Rachel HaywoodMartin Lee
Mar 23, 2007·Pharmacology & Therapeutics·Leslie P Lund, Graham S Timmins
Oct 16, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jordan ChangRonald B Walter
Apr 17, 2009·Experimental Dermatology·Przemyslaw M Plonka
Nov 7, 2006·Pigment Cell Research·Paul Meredith, Tadeusz Sarna
Feb 21, 2013·Pigment Cell & Melanoma Research·Shosuke ItoKazumasa Wakamatsu
Jan 14, 2010·Experimental Dermatology·Anna-Katharina von ThalerMark Berneburg
Jul 6, 2014·Pigment Cell & Melanoma Research·Ana Paula BenaduceLidia Kos
Oct 2, 2014·Journal of Fish Diseases·H Rahmati-HolasooB Mohammadian
Sep 4, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ronald B WalterMarkita G Savage
Aug 10, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yuan LuRonald B Walter
Aug 11, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·William BoswellRonald B Walter
May 4, 2015·Journal of Photochemistry and Photobiology. B, Biology·Jakub RokDorota Wrześniok
Nov 19, 2014·PloS One·Orlando Chiarelli-NetoMaurício S Baptista

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
D L MitchellIrma Gimenez-Conti
Proceedings of the National Academy of Sciences of the United States of America
R B SetlowA D Woodhead
© 2021 Meta ULC. All rights reserved