UV cross-linked dextran methacrylate--concanavalin A methacrylamide gel materials for self-regulated insulin delivery

Drug Development and Industrial Pharmacy
M Joan TaylorTarsem Sahota

Abstract

In this study, the successful acrylic derivatization of dextran and concanavalin A (con A) to form dextran methacrylate and con A methacrylamide is shown. These derivatized acrylic monomers are then photopolymerized in the presence of a water soluble photoinitiator Irgacure under various conditions to form covalently bonded glucose-responsive gel materials, which undergo a transformation to sol in the presence of free glucose. Rheological data have revealed that as the degree of substitution for dextran methacrylate is increased, a more elastic material is produced due to the increased covalent linkages. Some of these gel systems show negligible component loss in in vitro diffusion experiments used to simulate the behavior of the cross-linked gel, as would be used in a self-regulated insulin delivery device.

References

Jun 1, 1975·Archives of Biochemistry and Biophysics·A M FelixM Weigele
Dec 19, 1972·Biochemistry·K D Hardman, C F Ainsworth
Jul 1, 1974·Archives of Biochemistry and Biophysics·S De BernardoS Udenfriend
Feb 1, 1996·Analytical Biochemistry·R EhwaldH Dautzenberg
May 20, 1998·Journal of Biomaterials Science. Polymer Edition·T LiK Park
Jul 3, 1999·Nature·T MiyataT Uragami
Dec 1, 1999·The Journal of Pharmacy and Pharmacology·S TannaG Adams
Dec 22, 1999·Journal of Biomedical Materials Research·S H Kim, C C Chu
Jun 6, 2000·Advanced Drug Delivery Reviews·P M Graves, G S Eisenbarth
Jun 6, 2000·Advanced Drug Delivery Reviews·J Brange, A Vølund
Mar 21, 2001·Biotechnology & Genetic Engineering Reviews·G AdamsM J Taylor
Mar 22, 2001·Advanced Drug Delivery Reviews·J Kost, R Langer
Jul 28, 2001·Pharmaceutical Research·J J Kim, K Park
Nov 2, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J J Kim, K Park
Nov 17, 2001·Biomacromolecules·A I Van Den BulckeH Berghmans
Jan 5, 2002·Advanced Drug Delivery Reviews·Takashi MiyataKatsuhiko Nakamae
Nov 22, 2002·Journal of Drug Targeting·S TannaM J Taylor
Feb 6, 2003·Biotechnology and Bioengineering·M TangJ Hubble
Sep 27, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Joan TaylorBarbara Voermans

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Citations

May 30, 2012·Annals of the New York Academy of Sciences·Daniel F BerensonMichael A Weiss
Aug 20, 2019·Advanced Materials·Jinqiang WangZhen Gu
Oct 24, 2017·Advanced Healthcare Materials·Ghorbanali Sharifzadeh, Hossein Hosseinkhani
Dec 29, 2020·Chemical Reviews·Stephanie FuchsMinglin Ma
Sep 10, 2011·Chemical Reviews·Qian WuZhefu Chen

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